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Merck
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Principaux documents

G1921

Sigma-Aldrich

Glypican 3

recombinant, expressed in NSO cells

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About This Item

Code UNSPSC :
12352202
Nomenclature NACRES :
NA.26

Source biologique

human

Niveau de qualité

200

Produit recombinant

expressed in NSO cells

Essai

≥97% (SDS-PAGE)

Forme

lyophilized powder

Numéro d'accès UniProt

P51654

Température de stockage

−20°C

Informations sur le gène

human ... GPC3(2719)

Description générale

Glypican-3, a cell surface protein, is highly expressed in hepatocellular carcinoma (HCC) and few other human cancers including melanoma. It is a heparan sulfate proteoglycan and is present on the cell surface. Under non-reducing conditions in SDS-PAGE, the glycanated glypican 3 appears as a smear with an apparent molecular mass of 60 - 100 kDa†

Actions biochimiques/physiologiques

Sulfate proteoglycan attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor. Regulates cell survival and inhibits cell proliferation during normal development. Potential use as marker for early disease detection.

Forme physique

Lyophilized from a 0.2 μm filtered solution in PBS containing 50 μg of bovine serum albumin per 1 μg of cytokine.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
SLCJ8376
SLCJ8108
SLCJ0381
SLCH7127
SLBP4295V

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Consulter la Bibliothèque de documents

Yu-Liang Wang et al.
World journal of gastroenterology, 18(19), 2408-2414 (2012-06-02)
To investigate the diagnostic value of glypican-3 (GPC3) and its relationship with hepatocellular carcinoma (HCC) recurrence after liver transplantation. HCC tissue samples (n = 31) obtained from patients who had undergone liver transplantation were analyzed. GPC3 mRNA and protein expression
Shiro Suzuki et al.
Human vaccines & immunotherapeutics, 10(2), 338-343 (2013-11-21)
Carcinoembryonic antigen glypican-3 (GPC3) is expressed by>40% of ovarian clear cell carcinoma (CCC) and is a promising immunotherapeutic target. We previously reported the safety of and immunological and clinical responses to a GPC3-derived peptide vaccine in a phase I clinical
Restriction enzyme cleavage of UV-irradiated DNA: a comparison of far-UV and mid-UV wavelengths.
S P Moore et al.
Photochemistry and photobiology, 45(2), 253-263 (1987-02-01)

Articles

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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