A9210
Annexin V FITC Conjugate from human placenta
Synonyme(s) :
Annexin V, Calphosbindin I, Lipocortin V, PAP-1
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About This Item
Code UNSPSC :
41106305
Nomenclature NACRES :
NA.32
Produits recommandés
Forme
buffered aqueous solution
Niveau de qualité
Ampleur du marquage
1-2 mol FITC per mol annexin V
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
2-8°C
Informations sur le gène
human ... ANXA5(308)
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Application
For detection of apoptotic cells by flow cytometry or fluorescence microscopy.
Actions biochimiques/physiologiques
Annexins are ubiquitous homologous proteins that bind phospholipids in the presence of calcium. The cellular changes involved in the apoptotic process include loss of phospholipid asymmetry during the early stages. This phenomenon is universal and is not limited to stimulus or to mammalian cells, but also occurs in insect and plant cells. In living cells, phosphatidylserine is transported to the inside of the lipid bilayer by the Mg2+ATP dependent enzyme, aminophospholipid translocase. At the onset of apoptosis, phosphatidylserine becomes translocated to the external surface of the cell membrane. Since the movement of phosphatidylserine from the internal membrane surface to the external surface is an early indicator of apoptosis, annexin V and its conjugates that interact strongly and specifically with phosphatidylserine may be used to detect apoptosis. Annexin V conjugates can be used to detect apoptotic cells significantly earlier than DNA-based assays. Fluorescent dye labeled annexin V have applications in flow cytometry, fluorescence microscopy, and laser scanning cytometry.
Conditionnement
Package size based on protein content
Forme physique
Solution in 50 mM Tris-HCl, pH 7.5, containing 100 mM NaCl.
Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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