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A5730

Sigma-Aldrich

Abz-SDK(Dnp)P-OH trifluoroacetate salt

≥91% (HPLC), lyophilized powder

Synonyme(s) :

o-aminobenzoic acid-Ser-Asp-Lys(DNP)Pro-OH trifluoroacetate salt

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About This Item

Formule empirique (notation de Hill):
C31H38N8O13 · xC2HF3O2
Numéro CAS:
1217465-57-0
Poids moléculaire :
730.68 (free base basis)
Numéro MDL:
MFCD09753055
Code UNSPSC :
12352200
ID de substance PubChem :
24891013
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥91% (HPLC)

Forme

lyophilized powder

Solubilité

H2O: freely soluble

Température de stockage

2-8°C

Chaîne SMILES 

OC(=O)C(F)(F)F.Nc1ccccc1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCNc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)C(=O)N3CCC[C@H]3C(O)=O

InChI

1S/C31H38N8O13.C2HF3O2/c32-19-7-2-1-6-18(19)27(43)36-23(16-40)29(45)35-22(15-26(41)42)28(44)34-21(30(46)37-13-5-9-24(37)31(47)48)8-3-4-12-33-20-11-10-17(38(49)50)14-25(20)39(51)52;3-2(4,5)1(6)7/h1-2,6-7,10-11,14,21-24,33,40H,3-5,8-9,12-13,15-16,32H2,(H,34,44)(H,35,45)(H,36,43)(H,41,42)(H,47,48);(H,6,7)/t21-,22-,23-,24-;/m0./s1

Clé InChI

IFSUGURCQHMSJS-JPIABUGISA-N

Amino Acid Sequence

Abz-Ser-Asp-Lys-DNP

Application

Abz-SDK(Dnp)P-OH trifluoroacetate is an Angiotensin Converting Enzyme (ACE) fluorescent peptide substrate that specifically binds to the N domain of ACE. Abz-SDK(Dnp)P-OH has been used to study tipifarnib-induced apoptosis in acute myeloid leukemia and multiple myeloma cells.

Actions biochimiques/physiologiques

Abz-SDK(Dnp)P-OH is an Angiotensin Converting Enzyme (ACE) fluorescent peptide substrate specific for the N domain for real time fluorescent assay (ACE, Peptidyl Dipeptidase, Kininase II, E.C. 3.4.15.1).

Caractéristiques et avantages

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Niranjan Yanamandra et al.
The Journal of pharmacology and experimental therapeutics, 337(3), 636-643 (2011-03-08)
A major contributing factor to the high mortality rate associated with acute myeloid leukemia and multiple myeloma is the development of resistance to chemotherapy. We have shown that the combination of tipifarnib, a nonpeptidomimetic farnesyltransferase inhibitor (FTI), with bortezomib, a
Christopher D Cerruti et al.
Analytical and bioanalytical chemistry, 401(1), 75-87 (2011-03-08)
Mass spectrometry imaging of lipids using MALDI-TOF/TOF mass spectrometers is of growing interest for chemical mapping of organic compounds at the surface of tissue sections. Many efforts have been devoted to the best matrix choice and deposition technique. Nevertheless, the
Jun Lu et al.
Bioorganic & medicinal chemistry, 18(21), 7628-7638 (2010-10-05)
An efficient synthesis has provided access to a novel α-tocopherol analogue (2), as well as its trifluoroacetate salt and acetate ester. An annulation reaction was used to establish the pyridinol core structure and a Stille coupling reaction was employed for

Articles

Angiotensin Receptors

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Angiotensin Receptors

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