8.51095

PyOxim

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

• Synonyme(s) : PyOxim, 1-Cyano-2-ethoxy-2-oxoethylideneaminooxy-tris-pyrrolidino-phosphonium hexafluorophosphate
• Formule empirique (notation de Hill): C₁₇H₂₉F₆N₅O₃P₂
• Numéro CAS: 153433-21-7
• Poids moléculaire : 527.38
• Numéro MDL: MFCD18643381
• Code UNSPSC : 12352126
• Nomenclature NACRES : NA.22

Propriétés

• product name: PyOxim, Novabiochem^®
• Niveau de qualité: 300
• Gamme de produits: Novabiochem^®
• Pureté: ≥99.0% (HPLC)
• Forme: powder
• Capacité de réaction: reaction type: Coupling Reactions
• Fabricant/nom de marque: Novabiochem^®
• Application(s): peptide synthesis
• Température de stockage: 15-25°C
• InChI: 1S/C17H29N5O3P.F6P/c1-2-24-17(23)16(15-18)19-25-26(20-9-3-4-10-20,21-11-5-6-12-21)22-13-7-8-14-22;1-7(2,3,4,5)6/h2-14H2,1H3;/q+1;-1/b19-16+;
• Clé InChI: RDWDVLFMPFUBDV-PXMDEAMVSA-N

Description

Description générale

PyOxim ^[1] is a novel reagent which mediates coupling reactions with efficiencies superior to HATU and PyBOP and comparable to COMU. It is has excellent solubility in DMF and is stable in solution under an inert atmosphere for two days. Unlike HATU and HBTU, it cannot cause chain terminating side reactions and is, therefore, ideal for the synthesis of cyclic peptides. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents.


Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] R. Subiros-Funosas, et al. (2010) Org. Biomol. Chem., 8, 3665.

Caractéristiques et avantages

• Mediates coupling with superior efficiency to PyBOP, TBTU, and HCTU
• Mediates coupling with low racemization or epimerization
• Ideal for fragment condensation and synthesis of cyclic peptides as the reagent cannot cause guanidinylation
• Excellent solubility in DMF and NMP

Remarque sur l'analyse

Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable