900848

4-Amino-2-trimethylsilanylethynyl-benzenesulfonyl fluoride

• Synonyme(s) : Amino sulfonyl fluoride TMS-alkyne, Probe building block
• Formule empirique (notation de Hill): C₁₁H₁₄FNO₂SSi
• Numéro CAS: 2088828-95-7
• Poids moléculaire : 271.38
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.22

Propriétés

• Forme: liquid
• Disponibilité: available only in USA
• Température de stockage: −20°C
• Chaîne SMILES: NC1=CC=C(S(=O)(F)=O)C(C#C[Si](C)(C)C)=C1

Description

Application

Used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and amine synthetic handle. When appended to a ligand or pharmacophore through its amine linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Autres remarques

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Informations sur la sécurité

• Pictogrammes: GHS02
• Mention d'avertissement: Danger
• Mentions de danger: H242
• Conseils de prudence: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Classification des risques: Self-react. C
• Code de la classe de stockage: 5.2 - Organic peroxides and self-reacting hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable