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222569

Sigma-Aldrich

Fomepizole

99%

Synonyme(s) :

4-Methylpyrazole

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About This Item

Formule empirique (notation de Hill):
C4H6N2
Numéro CAS:
7554-65-6
Poids moléculaire :
82.10
Numéro Beilstein :
105204
Numéro CE :
231-445-0
Numéro MDL:
MFCD00005245
Code UNSPSC :
12352100
ID de substance PubChem :
24853343
Nomenclature NACRES :
NA.22

Pureté

99%

Indice de réfraction

n20/D 1.495 (lit.)

Point d'ébullition

99-100 °C/6 mmHg (lit.)

Solubilité

alcohol: soluble(lit.)
water: soluble(lit.)

Densité

0.993 g/mL at 25 °C (lit.)

Chaîne SMILES 

Cc1cn[nH]c1

InChI

1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)

Clé InChI

RIKMMFOAQPJVMX-UHFFFAOYSA-N

Informations sur le gène

human ... ADH1A(124) , ADH1B(125) , ADH1C(126)

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Description générale

4-Methylpyrazole inhibits CYP2E1 activity. It also acts as alcohol dehydrogenase inhibitor.

Application

Fomepizole (4-Methylpyrazole) can be used as:
  • A reactant to prepare 4-methyl-1-phenyl-1H-pyrazole by reacting with bromobenzene via N-arylation using a copper catalyst.
  • A starting material for the synthesis of 4-methyl-3(5)-nitropyrazole by nitration.
  • A ligand in the preparation of gallium(III) complex of 4-methylpyrazole as potential antitumor and antiviral agent.

Useful as an antidote in methanol and ethylene glycol poisoning.

Actions biochimiques/physiologiques

Alcohol dehydrogenase inhibitor
Alcohol dehydrogenase inhibitor.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H315,H319,H335

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

204.8 °F - closed cup

Point d'éclair (°C)

96 °C - closed cup

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificats d'analyse (COA)

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