46945

Fluorescein isothiocyanate–dextran

average mol wt 70,000, (FITC:Glucose = 1:250)

• Synonym(s): FITC-Dextran 70, FITC–Dextran
• CAS Number: 60842-46-8
• UNSPSC Code: 12352201
• NACRES: NA.32
• MDL number: MFCD00131092

Properties

• biological source: synthetic
• Quality Segment: 100
• conjugate: FITC conjugate
• form: powder
• mol wt: average mol wt 70,000
• composition: (FITC:Glucose = 1:250)
• concentration: 90-100 % (w/w) (TRITC DEXTRAN)
• extent of labeling: ~0.004 mol/mol FITC glucose
• color: light orange to very dark orange, light yellow to very dark yellow
• solubility: H₂O: 50 mg/mL, hazy, orange to very deep orange
• fluorescence: λ_ex 492 nm; λ_em 518 nm in ethanol
• application(s): cell analysis
• storage temp.: 2-8°C

Description

Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.

Fluorescein isothiocyanate–dextran (FITC-Dextran 70) is use as a fluorescent probe to study cell processes such as cell permeability, phagocytosis and endocytosis and to study mechanisms of biomolecular delivery. FITC-Dextran 70 may be used to study the capacity, selectivity and efficiency of encapsulation and release by drug delivery vehicles.

Other Notes

Internalisation of FITC and FITC-dextran by suspension cultured plant cells; In the study of fluid pinocytosis in leukocytes

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)
• Hazard Codes: H315,H319,H335