Yes, FITC-Dextran is frequently used for the study of migration, transport and perfusion in animals models. FITC-Dextran is readily detected in formalin-fixed samples. See the link below for a publication that may be helpful:
https://www.cell.com/cell-reports/pdf/S2211-1247(21)00510-6.pdf
90718
Fluorescein isothiocyanate–dextran
average Mw 70,000
Synonym(s):
FITC–Dextran 70, FITC–Dextran
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About This Item
Pricing and availability is not currently available.
biological source
synthetic
Quality Segment
conjugate
FITC conjugate
form
powder or crystals
mol wt
average Mw 70,000
extent of labeling
0.001-0.020 mol/mol FITC glucose
fluorescence
λex 493 nm; λem 520 nm±5 nm in 0.1 M Tris pH 8.0
application(s)
cell analysis
General description
Fluorescein isothiocyanate–dextran is an anionic fluorescent probe. The carboxyl group provides the negative charge, which improves the overall permeability of the molecule. It is supplied as a yellow powder that is freely soluble in water and electrolyte solutions. Fluorescein isothiocyanate–dextran is insoluble in most organic samples such as ethanol, methanol, acetone, and chloroform., however, it dissolves in DMSO, formamide, and a few other polar organic solvents.
Application
Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
Fluorescein isothiocyanate–dextran has an application of cell analysis, Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals. FITC-dextrans are primary source of studying permeability and transport in cells and tissues and can also be a tool for permeability studies of other materials.
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This Item | |||
|---|---|---|---|
| biological source synthetic | biological source synthetic | biological source synthetic | biological source bacterial (Leuconostoc mesenteroides) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| form powder or crystals | form powder or crystals | form powder or crystals | form powder |
| mol wt average Mw 70,000 | mol wt average mol wt 150,000 | mol wt average mol wt 2,000,000 | mol wt average mol wt 40,000 |
| extent of labeling 0.001-0.020 mol/mol FITC glucose | extent of labeling 0.001-0.020 mol/mol FITC glucose | extent of labeling 0.001-0.020 mol FITC per mol glucose (substitution) | extent of labeling 0.001-0.020 mol FITC per mol glucose |
| application(s) cell analysis | application(s) cell analysis | application(s) cell analysis | application(s) - |
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Is this FITC-Dextran compatible with formaldehyde fixation in animal tissues?
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