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Z0502

Zaleplon

Name: Zaleplon
Brand: SIGMA

≥98% (HPLC), solid

Synonym(e):

N-[3-(3-Cyanpyrazolo-[1,5-a]pyrimidin-7-yl)-phenyl)-N-ethyl-acetamid

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About This Item

Empirische Formel (Hill-System):

C₁₇H₁₅N₅O

CAS-Nummer:

151319-34-5

Molekulargewicht:

305.33

MDL-Nummer:

MFCD00867990

UNSPSC-Code:

12352200

PubChem Substanz-ID:

329831599

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Assay

≥98% (HPLC)

Form

solid

Arzneimittelkontrolle

USDEA Schedule IV; psychotrope (France); regulated under CDSA - not available from Sigma-Aldrich Canada

Lagerbedingungen

desiccated
protect from light

Farbe

white

Löslichkeit

DMSO: ~20 mg/mL
H₂O: insoluble

Lagertemp.

2-8°C

SMILES String

CCN(C(C)=O)c1cccc(c1)-c2ccnc3c(cnn23)C#N

InChI

1S/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3

InChIKey

HUNXMJYCHXQEGX-UHFFFAOYSA-N

Angaben zum Gen

human ... GABRA1(2554), GABRB1(2560), GABRG2(2566)

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Biochem./physiol. Wirkung

Zaleplon is a non-benzodiazepine agonist at the benzodiazepine site of the GABA_A receptor; sedative; hypnotic.

Leistungsmerkmale und Vorteile

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

GHS08,GHS07

Signalwort

Warning

H-Sätze

H336,H361f

P-Sätze

P202 - P261 - P271 - P280 - P304 + P340 + P312 - P308 + P313

Gefahreneinstufungen

Repr. 2 - STOT SE 3

Zielorgane

Central nervous system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

018K4711V

018K4711

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Zaleplon: a review of its use in the treatment of insomnia.

M Dooley et al.

Drugs, 60(2), 413-445 (2000-09-13)

Zaleplon is a pyrazolopyrimidine hypnotic agent which is indicated for the short term (2 to 4 weeks) management of insomnia. Zaleplon 5 and 10 mg at bedtime (usual recommended doses) significantly reduced sleep latency compared with placebo in clinical trials

Zaleplon: a pyrazolopyrimidine sedative-hypnotic agent for the treatment of insomnia.

K W Weitzel et al.

Clinical therapeutics, 22(11), 1254-1267 (2000-12-16)

Insomnia is the subjective complaint of poor sleep or an inadequate amount of sleep that adversely affects daily functioning. For the past 4 decades, treatment of insomnia has shifted away from the use of barbiturates toward the use of hypnotic

Long-term use of zopiclone, zolpidem and zaleplon among Danish elderly and the association with sociodemographic factors and use of other drugs.

Ane Birgitte Telén Andersen et al.

Pharmacoepidemiology and drug safety, 20(4), 378-385 (2011-01-25)

To estimate the degree of long-term use of zopiclone, zolpidem and zaleplon among Danes aged 65 and older and the association with sociodemographic factors and use of other drugs. Danish register-based study of 5000 men and 5000 women aged 65

Ultra high performance liquid chromatographic-tandem mass spectrometric multi-analyte procedure for target screening and quantification in human blood plasma: validation and application for 31 neuroleptics, 28 benzodiazepines, and Z-drugs.

Daniela Remane et al.

Analytical and bioanalytical chemistry, 401(4), 1341-1352 (2011-07-21)

For fast and reliable screening, identification, and quantification of as many analytes as possible, multi-analyte approaches are very useful in clinical and forensic toxicology. Using ultra high performance liquid chromatography-tandem mass spectrometry, such an approach has been developed for blood

Effect of hypnotic drugs on body balance and standing steadiness.

Monique A J Mets et al.

Sleep medicine reviews, 14(4), 259-267 (2010-02-23)

Disturbed body balance and standing steadiness are problematic for those who wake up at night or in the morning after using hypnotic drugs. As a result, falls and hip fractures are frequently reported in patients using sleep medication. A literature

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