V9389

Violacein

from Janthinobacterium lividum, >98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC), powder, bacterial metabolite

• Empirische Formel (Hill-System): C₂₀H₁₃N₃O₃
• CAS-Nummer: 548-54-9
• Molekulargewicht: 343.34
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: Violacein from Janthinobacterium lividum, >98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC)
• Qualitätsniveau: 200
• Assay: >98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC)
• Löslichkeit: H₂O: insoluble; acetone: soluble; ethanol: soluble; methanol: soluble
• Lagertemp.: 2-8°C
• SMILES String: N1C(=C\C(=C4/c5c(cccc5)NC/4=O)\C1=O)c2c3c([nH]c2)ccc(c3)O
• InChI: 1S/C20H13N3O3/c24-10-5-6-15-12(7-10)14(9-21-15)17-8-13(19(25)23-17)18-11-3-1-2-4-16(11)22-20(18)26/h1-9,21,24H,(H,22,26)(H,23,25)/b18-13-
• InChIKey: XAPNKXIRQFHCHN-AQTBWJFISA-N

Beschreibung

Allgemeine Beschreibung

Violacein from Janthinobacterium lividum is used as a colorant for natural and synthetic fabrics.[1] It functions as a respiratory pigment and regulates tryptophan production. Violacein exhibits anti-protozoal activity.[2]

Anwendung

Violacein from Janthinobacterium lividum has been used:

• for cell culture assays[3]
• as a standard to determine the crude violacein concentration in ethanol extracts of D. violaceinigra str. NI28 cultures[4]
• as a standard to identify violacein in the leaf samples of Nicotiana[5]

Biochem./physiol. Wirkung

Violacein is a member of a novel class of cytotoxic drugs, which mediate apoptosis. Violacein exhibits antitumoral, antibacterial, antiulcerogenic, antileishmanial, and antiviral activities.

Violacein, a violet pigment, is an indole derivative produced by various bacterial strains such as Chromobacterium violaceum, Janthinobacterium lividum, Chromobacterium lividum, and Pseudoalteromonas luteoviolacea. Violacein is a member of a novel class of cytotoxic drugs, which mediate apoptosis. Violacein exhibits antitumoral, antibacterial, antiulcerogenic, antileishmanial, and antiviral activities. Violacein and its β-cyclodextrin complexes trigger apoptosis and differentiation in HL60 leukemic cells. Violacein cytotoxicity is preceded by activation of caspase 8, transcription of NF-κB target genes, and p38-MAPK activation resembling TNF-α signal transduction.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)