This product is sourced from rice as stated on the product detail page.
T0452
D-α-Tocotrienol
from rice, ≥75% (GC)
Synonym(e):
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol
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About This Item
Empirische Formel (Hill-System):
C29H44O2
CAS-Nummer:
Molekulargewicht:
424.66
UNSPSC-Code:
12352205
NACRES:
NA.79
Preise und Verfügbarkeit sind derzeit nicht verfügbar.
Empfohlene Produkte
Biologische Quelle
rice
Qualitätsniveau
Assay
≥75% (GC)
Form
liquid
Farbe
colorless to brown
mp (Schmelzpunkt)
30-31 °C
Lagertemp.
−20°C
SMILES String
O1[C@@](CCc2c1c(c(c(c2C)O)C)C)(CC\C=C(\CC\C=C(\CCC=C(C)C)/C)/C)C
InChI
1S/C29H44O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h12,14,16,30H,9-11,13,15,17-19H2,1-8H3/b21-14+,22-16+/t29-/m1/s1
InChIKey
RZFHLOLGZPDCHJ-XZXLULOTSA-N
Verwandte Kategorien
Allgemeine Beschreibung
Biochem./physiol. Wirkung
α-Tocotrienol is an effective free radical scavengerand elicits protective functionality during oxidative stress in microsomes.[1] It is a strong antioxidant,[2] which reduces inflammation[4] and is used in cancer treatment.[3] α-tocotrienol supplementation may reduce cholesterol levels in hypercholesterolemia.[3] α-tocotrienol is neuroprotective as it blocks glutamate-induced cell death in neuronal cells.[5]
α-Tocotrienol may be used along with other isoforms to differentiate tocotrienol activities.
Tocotrienols are widely utilized for their strong antioxidant properties. The various isoforms of tocotrienols differ in their methyl substitution in the chromanol head. α-tocotrienol demonstrates neuroprotective properties by blocking glutamate-induced cell death in neuronal cells.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Vladimir Gogvadze et al.
International journal of cancer, 127(8), 1823-1832 (2010-01-28)
Release of mitochondrial proteins such as cytochrome c, AIF, Smac/Diablo etc., plays a crucial role in apoptosis induction. A redox-silent analog of vitamin E, alpha-tocopheryl succinate (alpha-TOS), was shown to stimulate cytochrome c release via production of reactive oxygen species
Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling
Packer L, et al.
The Journal of Nutrition, 131(2), 369S-373S (2001)
Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice
Qureshi AA, et al.
Lipids in Health and Disease, 9(1), 143-143 (2010)
Tomono Uchida et al.
Lipids, 47(2), 129-139 (2011-11-02)
The aim of this study was to evaluate tissue distribution of vitamin E isoforms such as α- and γ-tocotrienol and γ-tocopherol and interference with their tissue accumulation by α-tocopherol. Rats were fed a diet containing a tocotrienol mixture or γ-tocopherol
Yoshiro Saito et al.
Free radical biology & medicine, 49(10), 1542-1549 (2010-08-26)
Glutamate plays a critical role in pathological cell death within the nervous system. Vitamin E is known to protect cells from glutamate cytotoxicity, either by direct antioxidant action or by indirect nonantioxidant action. Further, α-tocotrienol (α-T3) has been reported to
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what is the source of Tocotrienol rice or rice bran oil
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