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Merck

SRP4903

Sigma-Aldrich

Adiponectin from rat

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(e):

ACDC, APM-1, Acrp30, AdipoQ, GBP-28

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

UNSPSC-Code:
12352202
NACRES:
NA.32

Biologische Quelle

rat

Rekombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

Form

lyophilized

Mol-Gew.

~30 kDa

Verpackung

pkg of 25 μg

Verunreinigungen

endotoxin, tested

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Angaben zum Gen

Allgemeine Beschreibung

Adiponectin (also called Acrp30, AdipoQ) is an adipocyte specific secreted protein[1] that circulates in the plasma. It is induced during adipocyte differentiation[1] and the secretion is stimulated by insulin.

Biochem./physiol. Wirkung

Adiponectin plays a role in various physiological processes such as energy homeostasis and obesity. Plasma levels of adiponectin are reduced in obese humans, and decreased levels are associated with insulin resistance and hyperinsulinemia. Adiponectin regulates vascular function, sustains an anti-inflammatory environment and promotes angiogenesis.[1][2]

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in 25 mM Tris, 0.15 M NaCl, pH 7.4 containing 50 μg of bovine serum albumin (BSA) per 1 μg of adiponectin.

Rekonstituierung

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Recontitute in PBS containing at least 0.1% BSA to a concentration of 0.1-1.0 mg/mL. This stock solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Deficiency of adiponectin protects against ovariectomy-induced osteoporosis in mice.
Wang F
PLoS ONE, 8(7), e68497-e68497 (2013)
Elevated adiponectin expression promotes adipose tissue vascularity under conditions of diet-induced obesity.
Aprahamian TR
Metabolism and Disease, 62(12), 1730-1738 (2013)
Sergio García-Méndez et al.
Medicine, 94(26), e935-e935 (2015-07-02)
The aim of this study was to determine the levels of leptin (Lep) and adiponectin (AdipoQ) in patients with gout and its relationship with joint inflammatory data and/or with metabolic syndrome (MetS) variables, during 1 year follow-up.Forty-one patients (40 males)
Marcia J Abbott et al.
PloS one, 10(7), e0134290-e0134290 (2015-08-01)
Epidemiological studies show that high circulating levels of adiponectin are associated with low bone mineral density. The effect of adiponectin on skeletal homeostasis, on osteoblasts in particular, remains controversial. We investigated this issue using mice with adipocyte-specific over-expression of adiponectin

Artikel

Lipid Induced Insulin Resistance

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