SML2264

Col003

≥98% (HPLC)

• Synonym(e): 2-Hydroxy-3-nitro-5-(phenylmethyl)benzaldehyde
• Empirische Formel (Hill-System): C₁₄H₁₁NO₄
• CAS-Nummer: 328565-16-8
• Molekulargewicht: 257.24
• MDL-Nummer: MFCD00852947
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: yellow to orange
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: OC1=C(C=C(C=C1C=O)CC2=CC=CC=C2)[N+]([O-])=O
• InChI: 1S/C14H11NO4/c16-9-12-7-11(6-10-4-2-1-3-5-10)8-13(14(12)17)15(18)19/h1-5,7-9,17H,6H2
• InChIKey: RKJXVCLOGNLZOI-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Col003 is a cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen. It binds to the collagen binding site on Hsp47. Col003 inhibits a collagen secretion by destabilization the collagen triple helix. Additionally Col003 weakly inhibits interaction of collagen with prolyl 4-hydroxylase (P4H).

cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable