SML1890

MK204

≥98% (HPLC)

• Synonym(e): 2-[5-Chloro-2-[[[(2,3,4,5,6-pentabromophenyl)methyl]amino]carbonyl]phenoxy]-acetic acid
• Empirische Formel (Hill-System): C₁₆H₉Br₅ClNO₄
• CAS-Nummer: 1959605-73-2
• Molekulargewicht: 714.22
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 3 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: O=C(C1=C(OCC(O)=O)C=C(C=C1)Cl)NCC(C(Br)=C(C(Br)=C2Br)Br)=C2Br
• InChI: 1S/C16H9Br5ClNO4/c17-11-8(12(18)14(20)15(21)13(11)19)4-23-16(26)7-2-1-6(22)3-9(7)27-5-10(24)25/h1-3H,4-5H2,(H,23,26)(H,24,25)
• InChIKey: QYSFXUVFRUYJCZ-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10).

MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10). AKR1B10 is induced in several cancer types, in particular, hepatocellular carcinoma, and may be involved with drug resistance. MK204 appears to target a distinct AKR1B10 inner specificity pocket not present in the closely related aldose reductase. MK204 had an IC₅₀ value of 80 nM compared to an IC₅₀ value of 21.7 μM for aldose reductase.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable