A7154

Adenosine, periodate oxidized

≥93%, synthetic, Powder

• Synonym(e): ADOX, Adenosine-2′,3′-dialdehyde
• Empirische Formel (Hill-System): C₁₀H₁₁N₅O₄
• CAS-Nummer: 34240-05-6
• Molekulargewicht: 265.23
• UNSPSC Code: 41106305
• PubChem Substance ID: 24891180
• NACRES: NA.51
• MDL number: MFCD00056960
• Assay: ≥93%
• Biological source: synthetic (organic)
• Form: powder
• Solubility: 0.2 M HCl: 50 mg/mL, clear, colorless to faintly yellow
• Storage temp.: −20°C

Eigenschaften

• Produktname: Adenosine, periodate oxidized, ≥93%
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥93%
• form: powder
• solubility: 0.2 M HCl: 50 mg/mL, clear, colorless to faintly yellow
• storage temp.: −20°C
• SMILES string: Nc1ncnc2n(cnc12)C(OC(CO)C=O)C=O
• InChI: 1S/C10H11N5O4/c11-9-8-10(13-4-12-9)15(5-14-8)7(3-18)19-6(1-16)2-17/h1,3-7,17H,2H2,(H2,11,12,13)
• InChI key: ILMNSCQOSGKTNZ-UHFFFAOYSA-N

Beschreibung

Application

Adenosine, periodate oxidized has been used:

• as a methylarginine transferase inhibitor in the human embryonic kidney (HEK)-293 T cells[1]
• as a methylase inhibitor in H4 neuroglioma[2]
• as a broad inhibitor of S-adenosylmethionine (AdoMet)-dependent methyltransferases in mouse embryo fibroblast NIH3T3 cells[3]

Biochem/physiol Actions

Adenosine, periodate oxidized (Adox) is a protein arginine methyltransferases (PRMTs) inhibitor.[4] It also inhibits the enzyme S-adenosylhomocysteine hydrolase and induces apoptosis.[5] Its inhibitory effect on histone methyltransferases prevents histone methylation.[6] Adox also elicits intrinsic cytotoxic properties.[1]

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type N95 (US)