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SML1537

Sigma-Aldrich

Cantharidin Ready Made Solution

0.1 mg/mL in DMSO

Synonym(e):

3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione, 7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran, Cantharidine, Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione

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About This Item

Empirische Formel (Hill-System):
C10H12O4
CAS-Nummer:
56-25-7
Molekulargewicht:
196.20
EG-Nummer:
200-664-3
UNSPSC-Code:
12352200
NACRES:
NA.77

Biologische Quelle

insect

Qualitätsniveau

200

Form

solution

Konzentration

0.1 mg/mL in DMSO

Versandbedingung

ambient

Lagertemp.

2-8°C

InChI

1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-

InChIKey

DHZBEENLJMYSHQ-XCVPVQRUSA-N

Biochem./physiol. Wirkung

It is a component of mylabris, a traditional Chinese medicine. Cantharidin exhibits anti-tumor activity. In addition, cantharidin can work against multidrug-resistant cells. In the epidermis, it causes release of neutral serine proteases, leading to degeneration of the desmosmal plaque. This results in acantholysis and intraepidermal blistering as well as skin lysis. PP2A is involved in the cell cycle, cell death, growth and cell-fate determination.
Cantharidin inhibits protein phosphatase 2A.

Sonstige Hinweise

Stable for at least two years at 2-8° C.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

188.6 °F

Flammpunkt (°C)

87 °C

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Wei Li et al.
Cancer science, 101(5), 1226-1233 (2010-03-25)
Cantharidin is an active constituent of mylabris, a traditional Chinese medicine. It is a potent and selective inhibitor of protein phosphatase 2A (PP2A) that plays an important role in control of cell cycle, apoptosis, and cell-fate determination. Owing to its
L Moed et al.
Archives of dermatology, 137(10), 1357-1360 (2001-10-27)
Cantharidin, a vesicant produced by beetles in the order Coleoptera, has a long history in both folk and traditional medicine. In dermatology, topical cantharidin has long been used to treat warts and molluscum. In 1962, cantharidin lost Food and Drug
Rolf Rauh et al.
Chinese medicine, 2, 8-8 (2007-07-06)
Herbal medicine is one of the forms of traditional medical practice. Traditional Chinese medicine (TCM) and traditional Vietnamese medicine (TVM) are well-known for their long-standing tradition of herbal medicine. Secreted by many species of blister beetle, most notably by the

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