SML1217

TG4-155

≥98% (HPLC)

• Synonym(e): (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
• Empirische Formel (Hill-System): C₂₃H₂₆N₂O₄
• CAS-Nummer: 1164462-05-8
• Molekulargewicht: 394.46
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: [n]2(c3c(cc2C)cccc3)CCNC(=O)\C=C\c1cc(c(c(c1)OC)OC)OC
• InChI: 1S/C23H26N2O4/c1-16-13-18-7-5-6-8-19(18)25(16)12-11-24-22(26)10-9-17-14-20(27-2)23(29-4)21(15-17)28-3/h5-10,13-15H,11-12H2,1-4H3,(H,24,26)/b10-9+
• InChIKey: YBHUXHFZLMFETJ-MDZDMXLPSA-N

Beschreibung

Biochem./physiol. Wirkung

TG4-155 is a brain penetrant prostaglandin EP2 specific antagonist.

TG4-155 is a brain penetrant prostaglandin EP2 specific antagonist. TG4-155 has a 4730X selectivity over EP4 (2.4 nM vs 11.4 mM in binding assays), and a 7 fold selectivity over DP1 receptors. TG4-155 crosses the blood brain barrier, and has no antagonistic effects on EP4 signaling, and displays neuroprotective effects in a pilocarpine-induced status epilepticus (SE) seizure model. TG4-155 does not interfere with G-protein function or phosphodiesterase activity, and does not inhibit COX-1 or COX-2.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable