SML0396

Tafenoquine succinate

≥95% (HPLC)

• Synonym(e): N-[2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine, SB-252263, WR 238605
• Empirische Formel (Hill-System): C₂₄H₂₈F₃N₃O₃ · C₄H₆O₄
• CAS-Nummer: 106635-81-8
• Molekulargewicht: 581.58
• MDL-Nummer: MFCD00892249
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825392
• NACRES: NA.77

Eigenschaften

• Assay: ≥95% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: DMSO: 5 mg/mL (clear solution)
• Lagertemp.: 2-8°C
• SMILES String: OC(=O)CCC(O)=O.COc1cc(C)c2c(Oc3cccc(c3)C(F)(F)F)c(OC)cc(NC(C)CCCN)c2n1
• InChI: 1S/C24H28F3N3O3.C4H6O4/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27;5-3(6)1-2-4(7)8/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3;1-2H2,(H,5,6)(H,7,8)
• InChIKey: CQBKFGJRAOXYIP-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Tafenoquine has been generally generated for oral administration and drug absorption increases when taken along with food.[1] It is known to possess a longer half life.[2]

Tafenoquine is an antimalarial primaquine analog being investigated to treat and prevent Plasmodium vivax infections. It can eliminate both blood and liver stages of Plasmodium vivax. Tafenoquine has also been tested as a therapy for leishmaniasis.

Tafenoquine is an antimalarial.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable