SML0393

QNZ46

≥98% (HPLC)

• Synonym(e): 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid
• Empirische Formel (Hill-System): C₂₄H₁₇N₃O₆
• CAS-Nummer: 1237744-13-6
• Molekulargewicht: 443.41
• MDL-Nummer: MFCD22666391
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825390
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 5 mg/mL (warmed; clear solution)
• Lagertemp.: room temp
• SMILES String: COc1ccc2N=C(\C=C\c3cccc(c3)[N+]([O-])=O)N(C(=O)c2c1)c4ccc(cc4)C(O)=O
• InChI: 1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+
• InChIKey: GNLVJIICVWDSNI-LFYBBSHMSA-N

Beschreibung

Biochem./physiol. Wirkung

QNZ46 is a noncompetitive inhibitor of GluN2C/D containing NMDA receptors. KD and IC₅₀ values for binding and inhibition of GluN1/Glun2D receptors by QNZ46 are 4.9 and 3.9 μM, respectively. QNZ46 does not compete for binding of glutamate or glycine, but QNZ46 receptor binding requires the binding of glutamate to the GluN2 subunit.

Leistungsmerkmale und Vorteile

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable