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Merck

SAB4502076

Sigma-Aldrich

Anti-Parkin antibody produced in rabbit

affinity isolated antibody

Synonym(e):

PARK2, PRKN, PRKN2, Parkinson disease protein 2, Parkinson juvenile disease protein 2

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 51 kDa

Speziesreaktivität

human

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... PRKN2(5071)

Allgemeine Beschreibung

The PRKN (parkin RBR E3 ubiquitin protein ligase) gene, also referred to as PARK2, is mapped to human chromosome 6q25.2–27. It is one of the largest genes in the human genome spanning a length of 1.53Mb. The gene consists of 12 exons and encodes a protein of 465 amino acids. It is broadly expressed in several tissues, including neurons, astrocytes, lung, colon and testes.

Anti-Parkin Antibody detects endogenous levels of total Parkin protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Parkin.

Immunogen Range: 101-150

Biochem./physiol. Wirkung

The PRKN (parkin RBR E3 ubiquitin protein ligase) gene encodes an E3 ubiquitin ligase that is involved in the maintenance of dopamine (DA) neuronal homeostasis. It ubiquitinates target proteins by interacting with ubiquitin-conjugating enzymes, such as UBCH7 (Ubiquitin-conjugating enzyme E2 L3) and UBCH8 (Ubiquitin/ISG15-conjugating enzyme E2 L6). Mutations in this gene have been linked to early-onset and progression of Parkinson′s Disease. Variations in this gene have also been associated with glioblastoma and other human malignancies.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Detection of Parkin (PARK2) and DJ1 (PARK7) mutations in early-onset Parkinson disease: Parkin mutation frequency depends on ethnic origin of patients.
Djarmati A, et al.
Human Mutation, 23(5), 525-525 (2004)
Mutations in PRKN and SNCA genes important for the progress of Parkinson?s disease.
Oczkowska A, et al.
Current Genomics, 14(8), 502-517 (2013)
Parkin genetics: one model for Parkinson's disease.
Mata I F, et al.
Human Molecular Genetics, 13(1), R127-R133 (2004)
Somatic mutations of the Parkinson's disease?associated gene PARK2 in glioblastoma and other human malignancies.
Veeriah S, et al.
Nature Genetics, 42(1), 77-77 (2010)

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