Direkt zum Inhalt
Merck

SAB4501395

Sigma-Aldrich

Anti-Acetyl-CoA Carboxylase, N-Terminal antibody produced in rabbit

affinity isolated antibody

Synonym(e):

ACCA

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise

Größe auswählen

100 μG
392,00 €

392,00 €


Auf LagerDetails



Größe auswählen

Ansicht ändern
100 μG
392,00 €

About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

392,00 €


Auf LagerDetails


Biologische Quelle

rabbit

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 265 kDa

Speziesreaktivität

mouse, rat, human

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... ACACA(31)

Allgemeine Beschreibung

Anti-Acetyl-CoA Carboxylase Antibody detects endogenous levels of total Acetyl-CoA Carboxylase protein.
Acetyl-CoA carboxylase 1 (ACC1) is a cytosolic enzyme. It is located on human chromosome 17q12.

Immunogen

The antiserum was produced against synthesized peptide derived from human Acetyl-CoA Carboxylase.

Immunogen Range: 46-95

Biochem./physiol. Wirkung

Acetyl-CoA carboxylase 1 (ACC1) catalyzes the rate-limiting step in de novo fatty acid biosynthesis. Acetyl-CoA is carboxylated to malonyl-CoA with the help of acetyl-CoA carboxylase (ACACA) in the fatty acid synthesis pathway. ACC1 is essential for the assembly of invadopodia.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sie haben nicht das passende Produkt gefunden?  

Probieren Sie unser Produkt-Auswahlhilfe. aus.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

Die passende Version wird nicht angezeigt?

Wenn Sie eine bestimmte Version benötigen, können Sie anhand der Lot- oder Chargennummer nach einem spezifischen Zertifikat suchen.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Translational control of human acetyl-CoA carboxylase 1 mRNA is mediated by an internal ribosome entry site in response to ER stress, serum deprivation or hypoxia mimetic CoCl2
Damiano F, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863(4), 388-398 (2018)
Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis
Scott K E N, et al.
PLoS ONE, 7(1), e29761-e29761 (2012)
Pietro Palumbo et al.
Gene, 538(2), 373-378 (2014-02-04)
Microdeletions of 17q12 including the hepatocyte nuclear factor 1 beta (HNF1B) gene, as well as point mutations of this gene, are associated with the Renal Cysts and Diabetes syndrome (RCAD, OMIM 137920) and genitourinary alterations. Also, microdeletions encompassing HNF1B were
Bruna Corominas-Faja et al.
Oncotarget, 5(18), 8306-8316 (2014-09-24)
Cancer stem cells (CSC) may take advantage of the Warburg effect-induced siphoning of metabolic intermediates into de novo fatty acid biosynthesis to increase self-renewal growth. We examined the anti-CSC effects of the antifungal polyketide soraphen A, a specific inhibitor of

Artikel

Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.

Fragen

Bewertungen

Kein Beurteilungswert

Aktive Filter

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.