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Key Documents

SAB2501506

Sigma-Aldrich

Anti-ZCCHC11 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-KIAA0191, Anti-bHLHa22, CCHC domain containing 11, PAP associated domain containing 3, Zinc finger

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

goat

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

canine, bovine, human, rat, mouse

Methode(n)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable

UniProt-Hinterlegungsnummer

Q5TAX3

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... ZCCHC11(23318)

Verwandte Kategorien

Allgemeine Beschreibung

Zinc finger CCHC-type containing 11 (ZCCHC11) is a 3′ terminal uridylyl transferase. It possesses multiple domains and has a molecular weight of about 185kDa. A fragment of the protein contains a TRF4 domain, a nucleotidyl transferase domain (NTD), two PAP-associated domains and three zinc finger domains. The ZCCHC11 gene is localized on human chromosome 1p32.3.

Immunogen

Peptide with sequence RERCPHPPRGNVSE, from the C-terminal region of the protein sequence according to NP_001009881.1; NP_056084.1; NP_001009882.1

Biochem./physiol. Wirkung

Zinc finger CCHC-type containing 11 (ZCCHC11) has a role in the RNA-binding protein Lin28 blockade of let-7 microRNA biogenesis. It is recruited by Lin28 to pre-let-7 (let-7 precursors), where it catalyzes the addition of an oligo (U)-tail.The protein is crucial for poly (A) tail length maintenance. ZCCHC11 also has a role in regulating the stability of transcripts for interleukin-6 and other cytokines.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Molecular similarity between myelodysplastic form of chronic
myelomonocytic leukemia and refractory anemia with ring
sideroblasts
Veronique Gelsi-Boyer
Haematologica (2012)
Identification of small molecule inhibitors of Zcchc11 TUTase activity.
Lin S and Gregory RI
RNA Biology, 12(8), 792-800 (2015)
Zcchc11-dependent uridylation of microRNA directs cytokine expression.
Jones MR, et.al
Nature Cell Biology, 11(9), 1157-1163 (2009)
Matthew R Jones et al.
Nature cell biology, 11(9), 1157-1163 (2009-08-25)
Mounting an effective host immune response without incurring inflammatory injury requires the precise regulation of cytokine expression. To achieve this, cytokine mRNAs are post-transcriptionally regulated by diverse RNA-binding proteins and microRNAs (miRNAs) targeting their 3' untranslated regions (UTRs). Zcchc11 (zinc-finger

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