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Merck

SAB1409827

Sigma-Aldrich

Anti-KIAA0319L antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Synonym(e):

KIAA1837, PKD1-like, PP791, RP4-765A10.3

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50 μG
417,00 €

417,00 €


Voraussichtliches Versanddatum25. April 2025



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50 μG
417,00 €

About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

417,00 €


Voraussichtliches Versanddatum25. April 2025


Biologische Quelle

mouse

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 115.6 kDa

Speziesreaktivität

human

Methode(n)

western blot: 1 μg/mL

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

Allgemeine Beschreibung

KIAA0319-like (KIAA0319L) protein is localized in the nucleus and cytoplasm. This protein is a type-I transmembrane protein with five immunoglobulin-like domains, known as polycystic kidney disease (PKD) domains present in the ectodomain. The KIAA0319L gene is mapped on the human chromosome at 1p34.3.

Immunogen

KIAA0319L (AAH14530.1, 1 a.a. ~ 1049 a.a) full-length human protein.

Sequence
MEKRLGVKPNPASWILSGYYWQTSAKWLRSLYLFYTCFCFSVLWLSTDASESRCQQGKTQFGVGLRSGGENHLWLLEGTPSLQSCLAACCQDSACHVFWWLEGMCIQADCSRPQSCRAFRTHSSNSMLVFLKKFQTADDLGFLPEDDVPHLLGLGWNWASWRQSPPRAALRPAVSSSDQQSLIRKLQKRGSPSDVVTPIVTQHSKVNDSNELGGLTTSGSAEVHKAITISSPLTTDLTAELSGGPKNVSVQPEISEGLATTPSTQQVKSSEKTQIAVPQPVAPSYSYATPTPQASFQSTSAPYPVIKELVVSAGESVQITLPKNEVQLNAYVLQEPPKGETYTYDWQLITHPRDYSGEMEGKHSQILKLSKLTPGLYEFKVIVEGQNAHGEGYVNVTVKPEPRKNRPPIAIVSPQFQEISLPTTSTVIDGSQSTDDDKIVQYHWEELKGPLREEKISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTANLTVNKAVDYPPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPSSKGKVVEMQGVRTPTLQLSAMQEGDYTYQLTVTDTIGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEKTQGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEINKPPIAKITGNVVITLPTSTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNHSDHHPILFLSNLVEGTYTFHLKVTDAKGESDTDRTTVEVKPDPRKNNLVEIILDINVSQLTERLKGMFIRQIGVLLGVLDSDIIVQKIQPYTEQSTKMVFFVQNEPPHQIFKGHEVAAMLKSELRKQKADFLIFRALEVNTVTCQLNCSDHGHCDSFTKRCICDPFWMENFIKVQLRDGDSNCEWSVLYVIIATFVIVVALGILSWTVICCCKRQKGKPKRKSKYKILDATDQESLELKPTSRAGIKQKGLLLSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKARSPREEIL

Biochem./physiol. Wirkung

KIAA0319-like (KIAA0319L) protein is involved in neuronal migration in the developing brain. It plays a role in learning and cognition. KIAA0319L works as a receptor for adeno-associated virus infection. KIAA0319L gene is considered a dyslexia susceptibility gene that is associated with developmental dyslexia, a common childhood learning disorder. Overexpression of the KIAA0319L gene is observed in peripheral blood cells from patients with systemic lupus erythematosus (SLE). KIAA0319L protein is linked with polycystic kidney disease.

Physikalische Form

Solution in phosphate buffered saline, pH 7.4

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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An essential receptor for adeno-associated virus infection.
Pillay S
Nature, 530, 108-108 (2016)
Antonio Velayos-Baeza et al.
Human molecular genetics, 17(6), 859-871 (2007-12-08)
The KIAA0319 gene has been recently associated with developmental dyslexia and shown to be involved in neuronal migration. The deduced KIAA0319 protein contains several polycystic kidney disease (PKD) domains which may mediate the interaction between neurons and glial fibres during
Guihong Song et al.
Reproductive biomedicine online, 30(3), 275-280 (2015-01-19)
KIAA0319L, PXK and JAZF1 gene polymorphisms were investigated to determine whether they conferred susceptibility to unexplained recurrent pregnancy loss (URPL) in a group of Chinese Han patients. Genotyping and sequencing of the single nucleotide polymorphisms (SNP) rs2275247(A/G) in KIAA0319L, rs2176082(C/T)
Luiz G Guidi et al.
Cerebral cortex (New York, N.Y. : 1991), 27(12), 5831-5845 (2017-10-19)
Developmental dyslexia is a neurodevelopmental disorder that affects reading ability caused by genetic and non-genetic factors. Amongst the susceptibility genes identified to date, KIAA0319 is a prime candidate. RNA-interference experiments in rats suggested its involvement in cortical migration but we
Jillian M Couto et al.
Journal of neurogenetics, 22(4), 295-313 (2008-12-17)
A locus on chromosome 1p34-36 (DYX8) has been linked to developmental dyslexia or reading disabilities (RD) in three independent samples. In the current study, we investigated a candidate gene KIAA0319-Like (KIAA0319L) within DYX8, as it is homologous to KIAA0319, a

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