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S3147

Sigma-Aldrich

5-Sulfosalicylsäure Dihydrat

suitable for electrophoresis, ≥99%

Synonym(e):

2-Hydroxy-5-Sulfobenzoesäure

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About This Item

Lineare Formel:
HO3SC6H3-2-(OH)CO2H·2H2O
CAS-Nummer:
5965-83-3
Molekulargewicht:
254.21
Beilstein:
650741
EG-Nummer:
202-555-6
MDL-Nummer:
MFCD00149540
UNSPSC-Code:
41105319
PubChem Substanz-ID:
24899547
NACRES:
NB.22

Assay

≥99%

Form

powder or crystals

Methode(n)

electrophoresis: suitable

Verunreinigungen

≤0.02% Insoluble matter
≤0.05% Salicylic Acid

mp (Schmelzpunkt)

105-110 °C (lit.)

Löslichkeit

water: soluble 100 mg/mL, clear, colorless

Anionenspuren

chloride (Cl-): ≤0.001%
sulfate (SO42-): ≤0.035%

Kationenspuren

Fe: ≤0.001%
heavy metals (as Pb): ≤0.002%

SMILES String

[H]O[H].[H]O[H].OC(=O)c1cc(ccc1O)S(O)(=O)=O

InChI

1S/C7H6O6S.2H2O/c8-6-2-1-4(14(11,12)13)3-5(6)7(9)10;;/h1-3,8H,(H,9,10)(H,11,12,13);2*1H2

InChIKey

BHDKTFQBRFWJKR-UHFFFAOYSA-N

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Allgemeine Beschreibung

5-Sulfosalicylic acid is a strong acid capable of protonating water. It forms a new theophylline complex, which was investigated by X-ray photoelectron spectroscopy (XPS). It forms 1:1 proton-transfer compounds with the ortho-substituted monocyclic heteroaromatic Lewis bases. Their crystal structures have been studied.

Anwendung

5-Sulfosalicylic acid (3.5%) in 12% trichloroacetic acid is commonly used as a fixing solution for proteins in agarose and polyacrylamide gels.
5-Sulfosalicylic acid dihydrate may be employed for the quantification of doxorubicin derived from PEGylated liposomal doxorubicin (Doxil) and its major metabolite in human plasma by HPLC. It may be used in the preparation of poly[[tris(di-2-pyridylamine)tris([μ]-5-sulfonatosalicylato)tricopper(II)] trihydrate].

Hinweis zur Analyse

Tested for use in fixing solutions for PAGE, SDS-PAGE and IEF.

Piktogramme

Corrosion
GHS05

Signalwort

Danger

H-Sätze

H314

Gefahreneinstufungen

Eye Dam. 1 - Skin Corr. 1B

Lagerklassenschlüssel

8A - Combustible corrosive hazardous materials

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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David L Chin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 779(2), 259-269 (2002-10-04)
A high-performance liquid chromatographic method was developed for the quantification of doxorubicin derived from PEGylated liposomal doxorubicin (Doxil) and its major metabolite in human plasma. This method utilizes Triton X-100 to disperse the liposome, followed by a protein precipitation step
Hui Wang et al.
Frontiers in physiology, 11, 655-655 (2020-07-01)
Serotonin (5-HT), a monoaminergic neurotransmitter, involves in the regulation of many physiological functions. In the present study, the effects of 5-hydroxytryptophan (5-HTP), the precursor of 5-HT, on lipid metabolism and intestinal immune function in broiler chickens were investigated in chickens.
Joanna S Stevens et al.
The journal of physical chemistry. B, 114(44), 13961-13969 (2010-10-22)
Recent studies suggested that X-ray photoelectron spectroscopy (XPS) sensitively determines the protonation state of nitrogen functional groups in the solid state, providing a means for distinguishing between co-crystals and salts of organic compounds. Here we describe how a new theophylline
Megan A Dickson et al.
Reproductive biology and endocrinology : RB&E, 18(1), 49-49 (2020-05-16)
Cigarette smokers have a reduced risk of developing preeclampsia, possibly attributed to an increase in carbon monoxide (CO) levels. Carbon monoxide is a gasotransmitter that has been implicated in maintaining vascular tone, increasing angiogenesis, and reducing inflammation and apoptosis at
Hydrogen bonding in proton-transfer compounds of 5-sulfosalicylic acid with ortho-substituted monocyclic heteroaromatic Lewis bases.
Smith G, et al.
Journal of Chemical Crystallography, 36(12), 841-849 (2006)
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