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S0520

Sigma-Aldrich

Selenocystamine dihydrochloride

>98% (TLC), suitable for ligand binding assays

Synonym(e):

2,2′-diselenobis-Ethanamine hydrochloride (1:2)

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About This Item

Empirische Formel (Hill-System):
C4H12N2Se2 · 2HCl
CAS-Nummer:
3542-13-0
Molekulargewicht:
318.99
MDL-Nummer:
MFCD00035445
UNSPSC-Code:
12352116
PubChem Substanz-ID:
24899440
NACRES:
NA.26

product name

Selenocystamine dihydrochloride, powder

Assay

>98% (TLC)

Form

powder

Methode(n)

ligand binding assay: suitable

Farbe

yellow to orange

Löslichkeit

H2O: soluble, clear to slightly hazy

SMILES String

NCC[Se][Se]CCN.[H]Cl.[H]Cl

InChI

1S/C4H12N2Se2.ClH/c5-1-3-7-8-4-2-6;/h1-6H2;1H

InChIKey

PKRYDZYGNSZBHO-UHFFFAOYSA-N

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Allgemeine Beschreibung

Selenocystamine dihydrochloride has a potential to block the activity of influenza A and B virus associated RNA-dependent RNA polymerase enzyme.

Anwendung

Selenocystamine dihydrochloride has been used to determine its effect on PP2A phosphatase activity in vitro. It has also been used as a catalyst for a disulfide-cleaving reagent, dithiothreitol (DTT).

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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Transferrin serves as a mediator to deliver organometallic ruthenium (II) anticancer complexes into cells
Guo W, et al.
Inorganic Chemistry, 52(9), 5328-5338 (2013)
Y Hou et al.
Biochemical and biophysical research communications, 228(1), 88-93 (1996-11-01)
Seleno compounds such as selenocystamine and seleno-D, L-cystine were found to catalyze the decomposition of S-nitrosothiols (e.g. S-nitroso-glutathione and S-nitroso-N-acetyl-D, L-penicillamine) in the presence of different thiols (e.g. glutathione, N-acetyl-D-penicillamine and 2-mercaptoethanol), and liberate nitric oxide. It was also found
Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer?s disease model
Corcoran NM, et al.
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 17(8), 1025-1033 (2010)
Yajun Weng et al.
Biomaterials, 32(5), 1253-1263 (2010-11-26)
Immobilization of selenocystamine on TiO(2) film deposited on silicon wafer and 316 stainless steel stents for catalytic generation of nitric oxide was described. Polydopamine was used as the linker for immobilization of selenocystamine to the TiO(2) surface. In vitro stability
M S Stewart et al.
Free radical biology & medicine, 26(1-2), 42-48 (1999-01-16)
The cancer chemopreventive effect of selenium cannot be fully accounted for by the role of selenium as a component of the antioxidant enzyme glutathione peroxidase, which suggests that chemoprevention occurs by another mechanism. Several studies have shown that thiol oxidation
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