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Wichtige Dokumente
P9018
Phorbol-12,13-didecanoat
solid
Synonym(e):
PDD, Phorbol-12,13-dicaprinat
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About This Item
Empirische Formel (Hill-System):
C40H64O8
CAS-Nummer:
Molekulargewicht:
672.93
Beilstein:
6036113
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
Empfohlene Produkte
Form
solid
Farbe
white
Löslichkeit
DMSO: soluble
ethanol: soluble
methanol: soluble
Lagertemp.
−20°C
SMILES String
[H][C@@]12C=C(CO)C[C@]3(O)C(=O)C(C)=C[C@@]3([H])[C@@]1(O)[C@H](C)[C@@H](OC(=O)CCCCCCCCC)[C@]4(OC(=O)CCCCCCCCC)C2C4(C)C
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Allgemeine Beschreibung
More potent than phorbol myristate acetate as an inflammatory agent, but weaker as a tumor promoting agent
Biochem./physiol. Wirkung
Strong NO promoter; potent activator of protein kinase C; promotes iNOS expression in cultured hepatocytes.
Vorsicht
Photosensitive
Rekonstituierung
A stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.
Lagerklassenschlüssel
13 - Non Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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K Hu et al.
The American journal of physiology, 276(2 Pt 2), H488-H495 (1999-02-10)
Both protein kinase C (PKC) and adenosine receptor activation have been shown to enhance ATP-sensitive K+ (KATP) channels. The present studies were designed to determine whether PKC mediates adenosine effects on the KATP channel. The dependence of KATP channel activity
Hiroki Kimura et al.
Schizophrenia bulletin, 41(3), 744-753 (2014-10-22)
Nuclear distribution E homolog 1 (NDE1), located within chromosome 16p13.11, plays an essential role in microtubule organization, mitosis, and neuronal migration and has been suggested by several studies of rare copy number variants to be a promising schizophrenia (SCZ) candidate
I Magiati et al.
Molecular autism, 6, 40-40 (2015-07-01)
There is growing research evidence that subclinical autistic traits are elevated in relatives of individuals with autism spectrum disorder (ASD), continuously distributed in the general population and likely to share common etiology with ASD. A number of measures have been
Leandro Francisco S Bastos et al.
European journal of pharmacology, 576(1-3), 171-179 (2007-08-28)
Tetracyclines induce anti-inflammatory effects unrelated to their antimicrobial activities. We investigated the effect induced by minocycline and doxycycline in models of nociceptive and inflammatory pain, edema, fever, cell migration and formation of fibrovascular tissue, as these effects have not been
Liliana Garneata et al.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 25(1), 67-74 (2014-09-15)
Periodontal disease (PDD) was associated with inflammation, malnutrition, and higher mortality in hemodialysis (HD) patients. Cross-sectional observational study, aiming to assess the prevalence of PDD and the possible relationship among PDD, inflammation, and malnutrition in HD patients. Single HD center
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