MAK202

Cathepsin S Inhibitor Screening Kit

Sufficient for 100 Fluorometric tests

• Synonym(e): CTSS Inhibitor Assay Kit
• UNSPSC-Code: 12352200

Eigenschaften

• Nachweisverfahren: fluorometric
• Relevante Krankheit(en): endocrinological disorders, diabetes; cardiovascular diseases; cancer
• Lagertemp.: −20°C
• Angaben zum Gen: human ... CTSS(1520) ; mouse ... CTSS(13040) ; rat ... CTSS(50654)

Beschreibung

Allgemeine Beschreibung

Cathepsin S (CTSS; EC 3.4.22.27) is a lysosomal cysteine proteinase involved in the degradation of proteins to peptides required for the presentation of MHC class II molecules.1 It is associated with pathological conditions such as atherosclerosis, coronary heart disease, cancer, and insulin resistance.

Eignung

Suitable for the screening of inhibitors of Cathepsin S.

Prinzip

The Cathepsin S Inhibitor Screening Kit is a simple assay for screening potential inhibitors of CTSS. CTSS activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λ_ex = 400/ λ_em = 505 nm), proportional to the enzymatic activity present.

Nur Kit-Komponenten

• CTSS Reaction Buffer
• Cathepsin S, human
• CTSS Substrate, Z-VVR-AFC, 10 mM
• CTSS Inhibitor Z-FF-FMK, 1 mM

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids