M5571

Miltefosine

≥98% (perchloric acid titration)

• Synonym(e): Choline hexadecyl phosphate, HePC, Hexadecyl phosphocholine
• Empirische Formel (Hill-System): C₂₁H₄₆NO₄P
• CAS-Nummer: 58066-85-6
• Molekulargewicht: 407.57
• MDL-Nummer: MFCD00133396
• UNSPSC-Code: 51191904
• PubChem Substanz-ID: 329818017
• NACRES: NA.85

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Beschreibung: zwitterionic
• Assay: ≥98% (perchloric acid titration)
• Form: powder
• Löslichkeit: H₂O: 10 mg/mL, clear, colorless
• Funktionelle Gruppe: phospholipid
• Lipid-Typ: phospholipids
• Lagertemp.: room temp
• SMILES String: [O-]P(OCC[N+](C)(C)C)(OCCCCCCCCCCCCCCCC)=O
• InChI: 1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3
• InChIKey: PQLXHQMOHUQAKB-UHFFFAOYSA-N

Beschreibung

Anwendung

• Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents.: This study underlines the necessity for innovative treatments amidst growing resistance to established drugs such as miltefosine which is used as a positive control reference, potentially setting a new direction for antileishmanial drug development (Ciccone et al., 2024).

Biochem./physiol. Wirkung

Inhibitor of protein kinase C and of phosphatidylcholine synthesis. Used for the treatment of visceral and cutaneous leishmaniasis. Active against metronidazole-resistant and -susceptible strains of Trichomonas vaginalis

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P264 - P270 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves