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I1774

Sigma-Aldrich

Iturin A from Bacillus subtilis

≥95% (HPLC), suitable for microbiological culture

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1 MG
322,00 €
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1.150,00 €

322,00 €

Versandbereit am07. April 2025Details

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1 MG
322,00 €
5 MG
1.150,00 €

About This Item

CAS-Nummer:
52229-90-0
MDL-Nummer:
MFCD01094135
UNSPSC-Code:
12352202
NACRES:
NA.61

322,00 €

Versandbereit am07. April 2025Details

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Produktbezeichnung

Iturin A from Bacillus subtilis, ≥95% (HPLC)

Biologische Quelle

Bacillus subtilis

Qualitätsniveau

200

Assay

≥95% (HPLC)

Form

powder

Methode(n)

microbiological culture: suitable

Farbe

white to yellow

Löslichkeit

ethanol: soluble 9.80-10.20 mg/mL

Wirkungsspektrum von Antibiotika

fungi

Wirkungsweise

cell membrane | interferes

Lagertemp.

2-8°C

Anwendung

Iturin A was used in the study of Bacillomycin D (an iturin with antifungal activity against Aspergillus flavus).[1]

Biochem./physiol. Wirkung

IturinA exhibits strong antifungal activity against pathogenic yeast and fungi.[2] It interacts with the cytoplasmic membrane of the target cell forming ion conducting pores[3]. Its mode of action could be attributed to its interaction with sterols and phospholipids. The compound causes the release of exo-vesicles from human erythrocytes.[4]

Sonstige Hinweise

A family of lipopeptides characterized by a heptapeptide cyclized with a C13-C17 β-amino fatty acid. Composed mainly of C14-C15 β-amino acids.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000410402
0000383063
0000383064
0000377029
0000410402

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M A Klich et al.
Mycopathologia, 127(2), 123-127 (1994-08-01)
The removal of many synthetic fungicides from the market has created a demand for new, environmentally safe fungicides. Iturin A, a cyclic lipopeptide produced by Bacillus subtilis, has strong antifungal properties and low mammalian toxicity. To determine the efficacy of
R Maget-Dana et al.
Toxicology, 87(1-3), 151-174 (1994-02-28)
Iturins are a family of lipopeptides extracted from the culture media of various strains of Bacillus subtilis. These amphiphilic compounds are characterized by a peptide ring of seven amino acid residues including an invariable D-Tyr2, with the constant chiral sequence
Scott W Pryor et al.
Journal of agricultural and food chemistry, 55(23), 9530-9536 (2007-10-24)
Partial least squares (PLS) regression modeling was used to relate the antifungal activity of Bacillus subtilis solid-state fermentation extracts to the individual high-performance liquid chromatography (HPLC) peaks from those extracts. A model was developed that predicted bioassay inhibition based on
Thimon, L., et al.
Cytobios, 79, 96-96 (1994)
Nopporn Thasana et al.
FEBS letters, 584(14), 3209-3214 (2010-06-15)
Subtulene A, a new cyclic lipopeptide, was isolated from the culture broth of Bacillus subtilis SSE4. This antibiotic compound contained the seven common alpha-amino acids, L-Asn-1, D-Tyr-2, D-Asn-3, L-Gln-4, L-Pro-5, D-Asn-6, L-Ser-7 and the unique beta-amino acid-8 present in the
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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 Antwort

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 Antwort

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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