H8876

5-Hydroxyindol-3-Essigsäure

≥98% (HPLC), crystalline

• Synonym(e): 5-Hydroxy-3-indolylessigsäure
• Empirische Formel (Hill-System): C₁₀H₉NO₃
• CAS-Nummer: 54-16-0
• Molekulargewicht: 191.18
• Beilstein: 168797
• EG-Nummer: 200-195-4
• MDL-Nummer: MFCD00005639
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 24278130
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: 5-Hydroxyindol-3-Essigsäure, ≥98% (HPLC), crystalline
• Qualitätsniveau: 200
• Assay: ≥98% (HPLC)
• Form: crystalline
• Farbe: white to purple
• mp (Schmelzpunkt): 161-164 °C (dec.) (lit.)
• Lagertemp.: −20°C
• SMILES String: OC(=O)Cc1c[nH]c2ccc(O)cc12
• InChI: 1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)
• InChIKey: DUUGKQCEGZLZNO-UHFFFAOYSA-N
• Angaben zum Gen: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363)

Beschreibung

Allgemeine Beschreibung

5-Hydroxyindole-3-acetic acid (5-HIAA) is the catabolic end product of serotonin pathway.[1] 5-HIAA is present in body fluids like cerebrospinal fluid (CSF), blood and urine. The expression levels of 5-HIAA is different among the normal and cancer patients.[2] Sepiapterin reductase deficiency results in low level of 5-HIAA in CSF.[1] 5-HIAA level is low in CSF in patients with bipolar 1 disorder with childhood attention-deficit hyperactivity disorder (ADHD).[3]

Anwendung

5-Hydroxyindole-3-acetic acid has been used as standard for the measurement of 5-HIAA in the brain tissue of mice using high performance liquid chromatography (HPLC).[4][5]

Biochem./physiol. Wirkung

Hauptserotonin-Metabolit

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)