H4413

Hydroxyfasudil hydrochloride hydrate

≥98% (HPLC), solid

• Synonym(e): 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate
• Empirische Formel (Hill-System): C₁₄H₁₇N₃O₃S · HCl · xH₂O
• CAS-Nummer: 155558-32-0
• Molekulargewicht: 343.83 (anhydrous basis)
• MDL-Nummer: MFCD06411567
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724499
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Zusammensetzung: The two peaks show the equilibrim between the two tautomers
• Farbe: white
• Löslichkeit: H₂O: >5 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: Cl[H].Oc1nccc2c(cccc12)S(=O)(=O)N3CCCNCC3
• InChI: 1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H
• InChIKey: XWWFOUVDVJGNNG-UHFFFAOYSA-N

Beschreibung

Anwendung

Hydroxyfasudil hydrochloride hydrate has been used as a ROCK inhibitor to study the role of different signaling pathways in the chemokines CCL19 and CCL21, the CCR7 ligands mediated effects on migratory and prosurvival, in CLL cells.[1]

Biochem./physiol. Wirkung

Hydroxyfasudil possessantispastic action. It is an active metabolite of fasudil. Hydroxyfasudil might enhance the dynamics of blood flow and prevent damage caused by neutrophils.[2]

Rho-kinase inhibitor.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves