Synthetic peptide sequence of ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 1.
Anwendung
Anti-ST8SIA1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem./physiol. Wirkung
α-N-acetylneuraminide α-2,8-sialyltransferase is an enzyme encoded by the ST8SIA1 gene in humans. It acts as an oligosialyltransferase in a cellular context. ST8SIA1 gene encodes a ganglioside synthase and is susceptibile to diseases. The gene is found to be associated with Multiple sclerosis (MS).
Physikalische Form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Journal of neuroimmunology, 212(1-2), 142-144 (2009-05-12)
Multiple sclerosis (MS) is a complex trait with a significant genetic component. Recent work has implicated the ST8SIA1 gene, encoding a ganglioside synthase, in susceptibility to the disease, perhaps with a parent-of-origin effect. In this investigation of 1318 MS patients
Glycosphingolipids from the ganglio-series are usually classified in four series according to the presence of 0 to 3 sialic acid residues linked to lactosylceramide. The transfer of sialic acid is catalyzed in the Golgi apparatus by specific sialyltransferases that show
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