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F3929
Anti-Follicle-Stimulating Hormone Receptor antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(e):
Anti-FSHR
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About This Item
Empfohlene Produkte
Biologische Quelle
rabbit
Qualitätsniveau
Konjugat
unconjugated
Antikörperform
affinity isolated antibody
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
buffered aqueous solution
Speziesreaktivität
human
Verfügbarkeit
not available in Japan
Methode(n)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 7-14 μg/mL
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... FSHR(2492)
mouse ... Fshr(14309)
rat ... Fshr(25449)
Allgemeine Beschreibung
Follicle stimulating hormone receptor (FSHR) belongs to the G protein-coupled receptors family and is a glycoprotein. FSHR gene is mapped to human chromosome 2p16.3. FSHR comprises hydrophilic domain, hydrophobic membrane regions, C-terminal extracellular domain, and short intracellular domain.
Immunogen
synthetic peptide coresponding to the N-terminal extracellular domain of human follicle-stimulating hormone receptor, conjugated to KLH. The immunizing peptide has 24% identity and 29% similarity with the mouse gene.
Anwendung
Anti-Follicle-Stimulating Hormone Receptor antibody produced in rabbit has also been used in immunohistochemistry in ovine and reproductive tissues. It has also been used in western blotting.[1]
Biochem./physiol. Wirkung
Follicle stimulating hormone receptor (FSHR) is located on Sertoli cells of the testes and the granulosa cells of ovary. The pituitary glycoprotein hormone, FSH, binds to FSHR and regulates the function of gonads and overall fertility. In Sertoli cells, FSHR-mediated cell proliferation determines the spermatogenic output. In ovarian granulosa cells, FSHR signaling mediates follicular growth and maturation of oocytes. Polymorphisms in the FSHR is implicated in premature ovarian insufficiency.
Physikalische Form
Solution in phosphate buffered saline containing 0.1% sodium azide.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
nwg
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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A T Grazul-Bilska et al.
Domestic animal endocrinology, 71, 106391-106391 (2019-11-16)
Corpus luteum (CL), a transient endocrine gland critical for reproductive cyclicity and pregnancy maintenance, is controlled by numerous regulatory factors. Although LH is widely recognized as the major regulator, other factors may also affect luteal functions. It has been demonstrated
Lingyuan Fu et al.
Journal of assisted reproduction and genetics, 30(5), 717-721 (2013-03-29)
Polycystic ovary syndrome (PCOS) is a common complex genetic endocrinopathy. It has high heritability, and twin studies indicate that it is a complex polygenic disorder. Searching for major genes of PCOS is crucial to clarify its molecular pathogenesis. A previous
Wenling Huang et al.
Reproductive biology and endocrinology : RB&E, 17(1), 80-80 (2019-10-21)
Whether follicle-stimulating hormone receptor (FSHR) polymorphisms are implicated in premature ovarian insufficiency (POI) remains controversial. Thus, we performed this study to explore correlation between FSHR polymorphisms and POI in human beings. Literature retrieve was conducted in PubMed, Medline, Embase and
The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology.
M Simoni et al.
Endocrine reviews, 18(6), 739-773 (1997-12-31)
Jitu W George et al.
Biology of reproduction, 84(1), 7-17 (2010-08-27)
Follicle-stimulating hormone (FSH), a pituitary glycoprotein hormone, is an integral component of the endocrine axis that regulates gonadal function and fertility. To transmit its signal, FSH must bind to its receptor (FSHR) located on Sertoli cells of the testis and
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