D5569

DCHC

≥98% (HPLC), solid

• Synonym(e): 3-(2,4-Dichlorophenyl)-7-hydroxy-4H-chromen-4-one
• Empirische Formel (Hill-System): C₁₅H₈Cl₂O₃
• CAS-Nummer: 302953-06-6
• Molekulargewicht: 307.13
• MDL-Nummer: MFCD01848896
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329798809
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Farbe: yellow
• Löslichkeit: DMSO: >20 mg/mL
• SMILES String: Oc1ccc2C(=O)C(=COc2c1)c3ccc(Cl)cc3Cl
• InChI: 1S/C15H8Cl2O3/c16-8-1-3-10(13(17)5-8)12-7-20-14-6-9(18)2-4-11(14)15(12)19/h1-7,18H
• InChIKey: QMSGNLMBWFRALO-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

DCHC is a SIRT1 activator. It increases peroxisome proliferator-activated receptor gamma co-activator 1α (PGC1α) expression, resulting in mitochondrial biogenesis.

DCHC is a SIRT1 activator. It increases peroxisome proliferator-activated receptor gamma co-activator 1α (PGC1α) expression, resulting in mitochondrial biogenesis. DCHC activates SIRT1 at low micromolar concentrations (5–10 μM) and increases SIRT1 activity at 100 μM. It is different from 5,7,4′-T in that it induces the activation of recombinant SIRT1, but does not increase SIRT1 expression.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P264 - P270 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges