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D4434

Sigma-Aldrich

Dichloromethylenediphosphonic acid disodium salt

Synonym(e):

Cl2MDP, Clodronate disodium, Clodronic acid disodium salt, DMDP

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1 G
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About This Item

Lineare Formel:
CH2O6Cl2Na2P2
CAS-Nummer:
22560-50-5
Molekulargewicht:
288.86
EG-Nummer:
245-078-9
MDL-Nummer:
MFCD01632786
UNSPSC-Code:
12352106
PubChem Substanz-ID:
24278371
NACRES:
NA.77

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Form

powder

Qualitätsniveau

300

Löslichkeit

water: 49.00-51.00 mg/mL, clear, colorless

Lagertemp.

room temp

SMILES String

[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O

InChI

1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

InChIKey

HJKBJIYDJLVSAO-UHFFFAOYSA-L

Angaben zum Gen

rat ... Man2a1(25478) , Si(497756)

Verwandte Kategorien

Biochem./physiol. Wirkung

Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma.[1][2] When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver.[3] Found also to inhibit collagenase and matrix metalloproteinase1.[4]

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000369112
0000315047
0000369112
0000315047
0000232917

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Michiko Itoh et al.
PloS one, 8(12), e82163-e82163 (2013-12-19)
Although macrophages are thought to be crucial for the pathogenesis of chronic inflammatory diseases, how they are involved in disease progression from simple steatosis to non-alcoholic steatohepatitis (NASH) is poorly understood. Here we report the unique histological structure termed "hepatic
Valérie Lebrun et al.
Clinical science (London, England : 1979), 125(11), 501-511 (2013-06-14)
Alcohol consumption is a major cause of liver disease. It also associates with increased cardiovascular risk and Type 2 diabetes. ALD (alcoholic liver disease) and NAFLD (non-alcoholic fatty liver disease) share pathological features, pathogenic mechanisms and pattern of disease progression.
N Van Rooijen
Journal of immunological methods, 124(1), 1-6 (1989-11-13)
Macrophages form an important cell population involved in numerous immunological processes. Techniques which eliminate these cells, in order to permit 'in vivo' studies of their function are generally imperfect and for that reason we have developed a method using the
Fabricio Montalvao et al.
The Journal of clinical investigation, 123(12), 5098-5103 (2013-11-02)
Anti-CD20 Ab therapy has proven successful for treating B cell malignancies and a number of autoimmune diseases. However, how anti-CD20 Abs operate in vivo to mediate B cell depletion is not fully understood. In particular, the anatomical location, the type
O Teronen et al.
Calcified tissue international, 61(1), 59-61 (1997-07-01)
Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an
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