D3900

Desipramin -hydrochlorid

≥98% (TLC), powder, imipramine metabolite

• Empirische Formel (Hill-System): C₁₈H₂₂N₂ · HCl
• CAS-Nummer: 58-28-6
• Molekulargewicht: 302.84
• EG-Nummer: 200-373-1
• MDL-Nummer: MFCD00058108
• UNSPSC-Code: 12352116
• PubChem Substanz-ID: 24278094
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: Desipramin -hydrochlorid, ≥98% (TLC), powder
• Assay: ≥98% (TLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: H₂O: 50 mg/mL
• Ersteller: Sanofi Aventis
• Lagertemp.: 2-8°C
• SMILES String: Cl[H].CNCCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H
• InChIKey: XAEWZDYWZHIUCT-UHFFFAOYSA-N
• Angaben zum Gen: human ... SLC6A2(6530)

Beschreibung

Allgemeine Beschreibung

Desipramine, a metabolite of imipramine and iofepramine is an active tricyclic antidepressant.[1]

Anwendung

Desipramine hydrochloride has been used:

• to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons[2]
• to protect unselective damage to the noradrenergic system[3]
• as a norepinephrine re-uptake inhibitor to treat rats for lesioning[4]

Biochem./physiol. Wirkung

Desipramine is used to treat depression. It is also used to manage enuresis in children.[1] Desipramine helps to eliminate the pain triggered by diabetic neuropathy.[5]

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (K_i = 4 nM) than the serotonin transporter (K_i = 61 nM).

Leistungsmerkmale und Vorteile

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Vorsicht

Hygroscopic

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H302,H315,H317,H319,H334,H335
• P-Sätze: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves