D3876

2′-Deoxyuridine 5′-monophosphate disodium salt

Sigma Grade

• Synonym(e): dUMP
• Lineare Formel: C₉H₁₁N₂O₈PNa₂
• CAS-Nummer: 42155-08-8
• Molekulargewicht: 352.15
• EG-Nummer: 255-687-1
• MDL-Nummer: MFCD00065282
• UNSPSC-Code: 41106305
• PubChem Substanz-ID: 24893787
• NACRES: NA.51

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualität: Sigma Grade
• Assay: ≥98% (HPLC)
• Form: powder
• Lagertemp.: −20°C
• SMILES String: [Na].OC1CC(OC1COP(O)(O)=O)N2C=CC(=O)NC2=O
• InChI: 1S/C9H13N2O8P.Na.H/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17;;/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17);;
• InChIKey: WXIVKKBDJOCRNB-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP).[1]

Anwendung

2′-Deoxyuridine 5′-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.

2′-Deoxyuridine 5′-monophosphate disodium salt has been used:

• in ultraperformance liquid chromatography-tandem mass spectrometry (UPLC/MS/MS) assay[1]
• to stimulate proliferation of peripheral blood mononuclear cell (PBMCs) exposed to influenza virus antigen[2]
• in thymidylate synthase activity assay Helicobacter pylori[3]

Biochem./physiol. Wirkung

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) conversion to pyrimidine is inhibited by methotrexate.[1] The inhibition of dUMP to deoxythymidine monophosphate (dTMP) at the methylation step is a key in controlling bacterial and eukaryotic cell growth.[3]

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves