Direkt zum Inhalt
Merck
Alle Fotos(1)

Wichtige Dokumente

Gesamtdokumentation anzeigen

B3306

Sigma-Aldrich

Bisindolylmaleimide IV

≥98% (TLC), solid

Synonym(e):

Ro 31-6233

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise

Größe auswählen

1 MG
85,90 €

85,90 €

Auf LagerDetails

Bulk-Bestellung anfordern
Alle Fotos(1)

Größe auswählen

Ansicht ändern
1 MG
85,90 €

About This Item

Empirische Formel (Hill-System):
C20H13N3O2
CAS-Nummer:
119139-23-0
Molekulargewicht:
327.34
MDL-Nummer:
MFCD00236432
UNSPSC-Code:
12352111
PubChem Substanz-ID:
24891709
NACRES:
NA.77

85,90 €

Auf LagerDetails

Bulk-Bestellung anfordern

Biologische Quelle

synthetic (organic)

Qualitätsniveau

200

Assay

≥98% (TLC)

Form

solid

Farbe

dark red

Löslichkeit

DMSO: soluble
methanol: soluble

Lagertemp.

−20°C

SMILES String

O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c4c[nH]c5ccccc45

InChI

1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)

InChIKey

DQYBRTASHMYDJG-UHFFFAOYSA-N

Angaben zum Gen

human ... CDK2(1017) , EGFR(1956)
rat ... Prkca(24680)

Biochem./physiol. Wirkung

Bisindolylmaleimides (BIM) comprises a group of 11 compounds from BIM-I to BIM-XI.[1] BIMs act as an inhibitor of protein kinase C (PKC).[1] They are derived from staurosporine.[2] BIM IX due to its proapoptotic functionality could be useful in targeting tumor proliferation.[3]

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000346320
0000346320
SLCQ4940
SLCQ3584
SLCN2754

Die passende Version wird nicht angezeigt?

Wenn Sie eine bestimmte Version benötigen, können Sie anhand der Lot- oder Chargennummer nach einem spezifischen Zertifikat suchen.

Suche nach COA

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Sibasish Dolai et al.
Proteomics, 11(13), 2683-2692 (2011-06-02)
Basal-like breast cancers are commonly negative for expression of estrogen and progesterone receptors and HER-2 (triple-negative breast cancer), which makes this subtype of breast cancers more aggressive and less responsive to standard treatment. We have applied a small-scale chemical proteomics
Abdullah Mayati et al.
PloS one, 10(12), e0144667-e0144667 (2015-12-15)
Ro 31-8220 is a potent protein kinase C (PKC) inhibitor belonging to the chemical class of bisindolylmaleimides (BIMs). Various PKC-independent effects of Ro 31-8220 have however been demonstrated, including inhibition of the ATP-binding cassette drug transporter breast cancer resistance protein.
Hui He et al.
The Prostate, 70(10), 1119-1126 (2010-03-25)
We have reported that human prostate cancer ARCaP(E) cells undertake epithelial to mesenchymal transition (EMT) when stimulated by certain soluble factors, and that EMT is regulated by surface receptor-elicited signaling pathways through protein phosphorylation. It is known that phorbol ester
Meng-Ling Chen et al.
The journal of pain : official journal of the American Pain Society, 13(10), 945-958 (2012-09-13)
The glial function in morphine tolerance has been explored, but its mechanisms remain unclear. Our previous study has showed that microglia-expressed P2X7 receptors (P2X7R) contribute to the induction of tolerance to morphine analgesia in rats. This study further explored the
Max Hoff et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(7), 2484-2491 (2011-04-12)
Rhythmic activity of cells and cellular networks plays an important role in physiology. In the nervous system oscillations of electrical activity and/or second messenger concentrations are important to synchronize neuronal activity. At the molecular level, rhythmic activity can be initiated
Alle zugehörigen Dokumente anzeigen

Fragen

Bewertungen

Kein Beurteilungswert

Aktive Filter

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.