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B3056

Sigma-Aldrich

Bisindolylmaleimide II

≥97% (Mixture of 2 isomers)

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About This Item

Empirische Formel (Hill-System):
C27H26N4O2
CAS-Nummer:
137592-45-1
Molekulargewicht:
438.52
MDL-Nummer:
MFCD00236430
UNSPSC-Code:
12352111
PubChem Substanz-ID:
329773212
NACRES:
NA.77

Biologische Quelle

synthetic (organic)

Qualitätsniveau

200

Assay

≥97% (Mixture of 2 isomers)

Form

powder

Löslichkeit

DMSO: soluble
ethanol: soluble

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26

InChI

1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33)

InChIKey

LBFDERUQORUFIN-UHFFFAOYSA-N

Anwendung

Bisindolylmaleimide II (BIS II) has been used:
  • as a protein kinase C (PKC) inhibitor to study its effects on cardiomyocyte phenotypes
  • as a PKC inhibitor along with methanandamide (mAEA) to study its effects on murine gastric vagal afferent (GVA) mechanosensitivity
  • as a PKC/protein kinase A (PKA) inhibitor to study its effects on bone-marrow cells

Biochem./physiol. Wirkung

Bisindolylmaleimide II (BIS II) acts as a dual protein kinase A/C (PKA/C) inhibitor.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Electrophoresis, 37(23-24), 3146-3153 (2016-10-27)
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