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A5737

Sigma-Aldrich

Cefotetan disodium

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About This Item

Empirische Formel (Hill-System):
C17H15N7Na2O8S4
CAS-Nummer:
74356-00-6
Molekulargewicht:
619.58
UNSPSC-Code:
51282206
NACRES:
NA.85

Form

powder

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria

Wirkungsweise

cell wall synthesis | interferes

Lagertemp.

2-8°C

InChI

1S/C17H17N7O8S4.2Na/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28;;/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30);;/q;2*+1/p-2/b12-6-;;/t13?,15-,17+;;/m1../s1

InChIKey

ZQQALMSFFARWPK-GLHLDKNHSA-L

Biochem./physiol. Wirkung

Cefotetan (cefotan) is a second-generation cephalosporin that is active against some strains of β-lactamase producing bacteria. It shows anti-microbial activity against Gram-positive and Gram-negative bacteria; it is more efficacious against Gram-negative and anaerobic bacteria. Cefotetan binds to penicillin-binding proteins and disrupts the cell wall synthesis.[1]
Cefotetan has good protein binding capacity due to its half-life of 3 to 4 hours. The presence of methylthiotetrazole (MTT) side chain helps to enhance its potential for hypoprothrombinemia and disulfiram reactions. It possesses high antimicrobial activity against gram-negative bacilli than cefoxitin.[2]

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000303923
0000303923
0000154946
0000154946
108M4867V

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R A Greenfield
The Journal of the Oklahoma State Medical Association, 86(1), 7-12 (1993-01-01)
Hopefully this review has brought some cephalosporin contentment to replace cephalosporin confusion. From the classification of these antibiotics in Table 1, we have made some significant reductions. One should know how to use cefazolin for staphylococcal/streptococcal infections and for surgical
George Garratty
Expert opinion on drug safety, 11(4), 635-642 (2012-04-17)
Drug-induced immune hemolytic anemia (DIIHA) is a rare cytopenia; about 130 drugs have been incriminated. The antibodies causing DIIHA can be i) drug-independent (drug not needed to be present to detect antibodies in vitro)-DIIHA caused by this type of antibody
Wookeun Lee et al.
The Korean journal of laboratory medicine, 29(5), 448-454 (2009-11-07)
Plasmid-mediated AmpC beta-lactamases (PABLs) have been detected in the strains of Escherichia coli, Klebsiella spp., Proteus mirabilis, and Salmonella spp. PABLs may be difficult to detect and might interfere in the therapeutic and infection-control processes. Although several PABL-detection methods based
Kamal M F Itani et al.
American journal of surgery, 193(2), 190-194 (2007-01-24)
The type of mechanical bowel preparation (MBP) used before elective colorectal surgery remains controversial. This post hoc analysis of a prospective randomized controlled antibiotic prophylaxis trial (ertapenem vs. cefotetan) evaluated the effect of polyethylene glycol (PEG) and sodium phosphate (SP)
Ellie J C Goldstein et al.
Surgical infections, 10(2), 111-118 (2009-02-20)
A randomized study comparing single-dose cefotetan and ertapenem prophylaxis for elective colorectal surgery in 1,002 patients found ertapenem to be significantly more effective (p < 0.001). Failures of prophylaxis were thought to involve organisms resistant to both antimicrobial agents, isolated
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