78825

Liquiritigenin

≥97.0% (HPLC)

• Synonym(e): 7,4′-Dihydroxyflavanon, 7-Hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-on
• Empirische Formel (Hill-System): C₁₅H₁₂O₄
• Molekulargewicht: 256.25
• Beilstein: 359378
• MDL-Nummer: MFCD00287289
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329768184
• NACRES: NA.28

Eigenschaften

• Assay: ≥97.0% (HPLC)
• Form: powder or crystals
• Verunreinigungen: ≤7% water
• Anwendung(en): metabolomics; vitamins, nutraceuticals, and natural products
• SMILES String: Oc1ccc(cc1)[C@@H]2CC(=O)c3ccc(O)cc3O2
• InChI: 1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1
• InChIKey: FURUXTVZLHCCNA-AWEZNQCLSA-N

Beschreibung

Allgemeine Beschreibung

Liquiritigenin is a flavonoid and an estrogenic compound found in licorice (Glycyrrhizae radix) root extract and several other plants.

Anwendung

Liquiritigenin has been used:

• to study its inhibitory effect on tumor metastasis in the treatment of colorectal cancer
• as a reference standard for ultra-performance liquid chromatography (UPLC) of Chaihu-Shugan-San (CSS) extract
• as a potential antiviral drug against hepatitis C virus (HCV) infection

Biochem./physiol. Wirkung

Liquiritigenin displays anti-diabetic and choleretic properties. It exerts anti-inflammatory activity on Raw246.7 cells by inhibiting nuclear factor kappa light chain enhancer of activated B cells (NF-κB)-dependent-induction of inducible NOS (iNOS). Liquiritigenin inhibits liver fibrogenesis by blocking Hippo/Yes-associated protein (YAP) and transforming growth factor-β1 (TGF-β1)/small mothers against decapentaplegic (Smad) components. It is a selective estrogen receptor β agonist cells. Liquiritigenin induces apoptosis in SMM-721 cells by disruption of the mitochondrial membrane potential and increased production of reactive oxygen species.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable