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I6659

Sigma-Aldrich

Imperatorin

≥98% (HPLC), powder

Synonym(e):

8-Isopentenyloxypsoralen, 9-(3-Methylbut-2-enyloxy)-7H-furo[3,2-g]chromen-7-on, 9-[(3-METHYL-2-BUTEN-1-YL)OXY]-7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE, Ammidin, Marmelid, Marmelosin

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About This Item

Empirische Formel (Hill-System):
C16H14O4
CAS-Nummer:
482-44-0
Molekulargewicht:
270.28
EG-Nummer:
207-581-1
MDL-Nummer:
MFCD00016881
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329815395
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

off-white to light brown

Löslichkeit

DMSO: ≥5 mg/mL

Lagertemp.

2-8°C

SMILES String

C\C(C)=C\COc1c2OC(=O)C=Cc2cc3ccoc13

InChI

1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3

InChIKey

OLOOJGVNMBJLLR-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
Imperatorin is an important bioactive furanocoumarin. It is used to treat neurodegenerative diseases. It possesses anticancer, antibacterial, anti-inflammatory and HIV replication-inhibiting activities. Imperatorin serves as an inhibitor of acetylcholinesterase (AChE) and may help in treating Alzheimer′s disease (AD) and Parkinson′s disease (PD).

Leistungsmerkmale und Vorteile

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Glycyrrhizinsäure United States Pharmacopeia (USP) Reference Standard

USP

1295888

Glycyrrhizinsäure

Umbelliferon 99%

Sigma-Aldrich

H24003

Umbelliferon

Glycyrrhizinsäure Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1516

Glycyrrhizinsäure

Yan Zhang et al.
Fitoterapia, 83(1), 60-66 (2011-10-11)
Augmented endothelial nitric oxide (NO) synthase (eNOS) signaling has been reported to be associated with improvements in cardiac remodeling, and NO levels have been shown to be related to cardiac hypertrophy and heart failure. Imperatorin, a dietary furanocoumarin, has been
Xia Lv et al.
Food chemistry, 138(4), 2260-2266 (2013-03-19)
Imperatorin (IMP) is a major constituent of many herbal medicines and possesses anti-osteoporosis activity. The present research work aimed to study the biotransformation processes of IMP and evaluated the anti-osteoporosis activity of the transformed metabolites. Among 18 strains of filamentous
Zhangqian Wang et al.
Pest management science, 68(7), 1041-1047 (2012-03-06)
An assessment was made of the toxicity of imperatorin and osthole identified in Cnidium monnieri fruit, 11 related compounds and five insecticides to larvae from insecticide-susceptible Culex pipiens pallens (KS-CP strain) and Aedes aegypti and wild C.p. pallens (YS-CP colony)
Weixiao Guo et al.
Inflammation, 35(6), 1764-1772 (2012-08-15)
Imperatorin is a type of coumarin compound with antibacterial and antiviral activities. In the present study, we examined the anti-inflammatory effects of imperatorin in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages by investigating its impact on the production and expression of cytokines
Ke-wang Luo et al.
Chemotherapy, 57(6), 449-459 (2011-12-23)
Imperatorin (IM) is a furanocoumarin isolated from the root of Angelica dahurica, which is reported to have anticonvulsant and anticancer effects. In this study, the antiproliferative effect of IM on 9 human cancer cell lines was examined, and human hepatoma
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