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Y0000517

Glutathion

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

L-Glutathion reduziert, γ-L-Glutamyl-L-cysteinyl-glycin, GSH

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About This Item

Lineare Formel:
H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
CAS-Nummer:
70-18-8
Molekulargewicht:
307.32
Beilstein:
1729812
MDL-Nummer:
MFCD00065939
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329830998
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

glutathione

Hersteller/Markenname

EDQM

mp (Schmelzpunkt)

192-195 °C (dec.) (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O

InChI

1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

InChIKey

RWSXRVCMGQZWBV-WDSKDSINSA-N

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Verwandte Kategorien

Amino Acid Sequence

γ-Glu-Cys-Gly

Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

In einer Konzentration von 5–10 mM kann es verwendet werden, um Glutathion-S-Transferase (GST) aus Glutathion-Agarose zu eluieren.

Biochem./physiol. Wirkung

Endogenes Antioxidans, das eine wesentliche Rolle bei der Reduktion von im Zellstoffwechsel und beim „oxidativen Burst“ gebildeten reaktiven Sauerstoffspezies spielt. Glutathion-S-Transferase katalysiert die Bildung von Glutathionthioethern mit Xenobiotika, Leukotrienen und anderen Molekülen mit einem elektrophilen Zentrum. Weiterhin bildet Glutathion in Proteinen Disulfidbindungen mit Cysteinresten. Aufgrund dieser Mechanismen kann es den paradoxen Effekt haben, die Wirkung von Antikrebsmitteln zu verringern.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number

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