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Y0000119

Hydroxycarbamid

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

Hydroxyharnstoff, Hydroxycarbamid

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About This Item

Lineare Formel:
NH2CONHOH
CAS-Nummer:
127-07-1
Molekulargewicht:
76.05
Beilstein:
1741548
MDL-Nummer:
MFCD00007943
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329830855
NACRES:
NA.24
Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Qualität

pharmaceutical primary standard

API-Familie

hydroxycarbamide

Hersteller/Markenname

EDQM

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

NC(=O)NO

InChI

1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)

InChIKey

VSNHCAURESNICA-UHFFFAOYSA-N

Angaben zum Gen

human ... RRM1(6240) , RRM2(6241) , RRM2B(50484)

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Hydroxycarbamide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem./physiol. Wirkung

Anti-neoplastisch. Inaktiviert die Ribonukleosid-Reduktase durch Bildung eines freien Nitroxid-Radikals, das ein freies Tyrosyl-Radikal im aktiven Zentrum des Enzyms bindet. Dadurch wird die Synthese von Desoxynukleotiden blockiert, was die DNA-Synthese hemmt und die Synchronisation oder den Zelltod in der S-Phase induziert.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

Ähnliches Produkt

Produkt-Nr.
Beschreibung
Preisangaben

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H340,H361

Gefahreneinstufungen

Muta. 1B - Repr. 2

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number

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Die Dokumentenbibliothek aufrufen

Nancy S Green et al.
Pediatric blood & cancer, 56(2), 177-181 (2010-09-11)
Fetal hemoglobin (HbF) levels are generally inversely proportional to severity of sickle cell disease (SCD) for given sickle phenotypes. Molecular regulation of HbF occurs through complex interactions cis and trans to the beta globin gene locus. Novel insights made through
Russell E Ware
Blood, 115(26), 5300-5311 (2010-03-13)
Hydroxyurea has many characteristics of an ideal drug for sickle cell anemia (SCA) and provides therapeutic benefit through multiple mechanisms of action. Over the past 25 years, substantial experience has accumulated regarding its safety and efficacy for patients with SCA.
Pilvi Riihilä et al.
The Journal of investigative dermatology, 135(2), 579-588 (2014-09-04)
The incidence of cutaneous squamous cell carcinoma (cSCC) is rising worldwide. We have examined the role of complement components in the progression of cSCC. Analysis of cSCC cell lines (n=8) and normal human epidermal keratinocytes (n=11) with whole transcriptome profiling
A Tefferi et al.
Leukemia, 28(12), 2300-2303 (2014-05-06)
The impact of calreticulin (CALR) mutations on long-term survival in essential thrombocythemia (ET) was examined in 299 patients whose diagnosis predated 2006. Mutational frequencies were 53% for Janus kinase 2 (JAK2), 32% for CALR and 3% for MPL; the remaining
John J Strouse et al.
Pediatrics, 122(6), 1332-1342 (2008-12-03)
Hydroxyurea is the only approved medication for the treatment of sickle cell disease in adults; there are no approved drugs for children. Our goal was to synthesize the published literature on the efficacy, effectiveness, and toxicity of hydroxyurea in children
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