PHR1146

Ibuprofen-verwandte Verbindung C

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): 4′-Isobutylacetophenon, 1-(4-Isobutyl-phenyl)-ethanon, 1-Acetyl-4-isobutyl-benzol
• Empirische Formel (Hill-System): C₁₂H₁₆O
• CAS-Nummer: 38861-78-8
• Molekulargewicht: 176.25
• EG-Nummer: 254-159-8
• UNSPSC-Code: 41116107
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material; pharmaceutical secondary standard
• Qualitätsniveau: 100; 300
• Agentur: traceable to BP 557; traceable to USP 1335541
• API-Familie: ibuprofen
• Analysenzertifikat (CofA): current certificate can be downloaded
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: 2-8°C
• SMILES String: O=C(C)c1ccc(cc1)CC(C)C
• InChI: 1S/C12H16O/c1-9(2)8-11-4-6-12(7-5-11)10(3)13/h4-7,9H,8H2,1-3H3
• InChIKey: KEAGRYYGYWZVPC-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

It is an impurity of the nonsteroidal anti-inflammatory drug (NSAID)― ibuprofen and presents itself as a degradation product of the parent drug. It is used for the treatment of mild and moderate pain such as during rheumatoid arthritis, osteoarthritis, and dysmenorrhea.[1]

Anwendung

This pharmaceutical secondary standard can also be used as follows:

• Simultaneous determination of ibuprofen and its 17 related impurities by an ICH validated reversed-phase high-performance liquid chromatography (RP-HPLC) method in tablets[1]
• Analysis of combined dosage tablet of ibuprofen and famotidine for their quantitative estimation in the presence of their impurities using thin layer chromatography (TLC) and HPLC

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAB2151 in the slot below. This is an example certificate only and may not be the lot that you receive.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H315,H317,H411
• P-Sätze: P261 - P264 - P272 - P273 - P280 - P302 + P352
• Gefahreneinstufungen: Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1B
• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): 286.7 °F - closed cup
• Flammpunkt (°C): 141.5 °C - closed cup