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D3525

Supelco

Diosmin

analytical standard

Synonym(e):

3′,5,7-Trihydroxy-4′-methoxyflavon-7-rutinosid, Barosmin, Buchu-Harz, Diosmetin-7-O-rhamnosylglucosid, Diosmetin-7-rutinosid

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About This Item

Empirische Formel (Hill-System):
C28H32O15
CAS-Nummer:
Molekulargewicht:
608.54
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24
Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Qualität

analytical standard

Qualitätsniveau

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

cleaning products
cosmetics
food and beverages
personal care

Format

neat

Lagertemp.

2-8°C

SMILES String

COc1ccc(cc1O)C2=CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2

InChI

1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1

InChIKey

GZSOSUNBTXMUFQ-YFAPSIMESA-N

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Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem./physiol. Wirkung

Citrus flavonoid. Modification of hesperidin. Studied for its chemopreventive properties, including anti-proliferative and anti-inflammatory.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Analysenzertifikate (COA)

Lot/Batch Number

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Jacqueline M Cohen et al.
Chest, 141(2), 308-320 (2012-02-09)
Postthrombotic syndrome (PTS) is a frequent, chronic complication of DVT. The effectiveness and safety of available treatments are unknown. The objective of this study was to systematically review the literature to assess whether pharmacologic and compression therapies are effective and
Subramani Srinivasan et al.
Chemico-biological interactions, 195(1), 43-51 (2011-11-08)
Oxidative stress has been suggested as a contributory factor in development and complication of diabetes. The aim of the study was to evaluate the effect of diosmin (DS) in oxidative stress in streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats by measuring the lipid
Mir Tahir et al.
Alcohol (Fayetteville, N.Y.), 47(2), 131-139 (2013-02-20)
The present investigation was designed to evaluate the efficacy of diosmin against ethanol-induced hepatotoxicity in rats by modulating various mechanisms including ethanol metabolizing enzymes, generation of free radicals, imbalance in oxidant-antioxidant status, oxidative damage to membrane lipids, activation of transcription
Chung Sim Lim et al.
Journal of vascular surgery, 56(4), 1069-1077 (2012-06-09)
Doxycycline and micronized purified flavonoid fraction (MPFF) modulate vein wall remodeling that may be associated with hypoxia in varicose veins (VVs), vein graft stenosis, and deep venous thrombosis. We recently reported that in vitro exposure of non-VV (NVVs) and VVs
Guy Lewin et al.
Journal of natural products, 76(1), 8-12 (2012-12-20)
Enhancement of the water solubility by disruption of molecular planarity has recently been reviewed as a feasible approach in small-molecule drug discovery programs. We applied this strategy to some natural flavone glycosides, especially diosmin, a highly insoluble citroflavonoid prescribed as

Fragen

1-5 von 5 Fragen  
  1. What is the Department of Transportation shipping information for this product?

    1 Antwort
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Hilfreich?

  2. How should Product D3525, Diosmin, be dissolved?

    1 Antwort
    1. Diosmin is soluble in DMSO at 10 mM, per following paper:Zhang, S., et al., "Flavonoids as Aryl Hydrocarbon Receptor Agonists/Antagonists: Effects of Structure and Cell Context." Environ. Health. Perspect., 111, 1877-1882 (2003).

      Hilfreich?

  3. Does Product D3525, diosmin absorb in the UV spectrum?  If so, what is the ?max?

    1 Antwort
    1. Yes. Diosmin has the following UV absorbance properties: λmax: 255 nm, 268 nm, 345 nm (ethanol) Extinction coefficient: EmM = 19.05, 17.78, and 19.95.Referenced from:  chemicals encyclopedia published by the Royal Society of Chemistry, 10th ed., Entry# 3300.

      Hilfreich?

  4. Is Product D3525, Diosmin, synthetic or from a natural source?

    1 Antwort
    1. Diosmin is typically isolated from a plant source (orange or lemon). This information can be found on Certificate of Origin (CofO lot-specific). The link to CofO is located on the Product Detail Page.

      Hilfreich?

  5. Product D3525, Diosmin, is a rutinoside derivative. Does Sigma-Aldrich list any other rutinosides?

    1 Antwort
    1. Yes, we have two others:  H5254, Hesperidin and 36428, Keracynin chloride.

      Hilfreich?

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