MAB4708

Anti-Caspase 8 Antibody, clone 1-1-37

clone 1-1-37, Chemicon^®, from mouse

• Synonym(e): MACH1, FLICE
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 1-1-37, monoclonal
• Speziesreaktivität: human
• Hersteller/Markenname: Chemicon^®
• Methode(n): western blot: suitable
• Isotyp: Not specified
• NCBI-Hinterlegungsnummer: NM_001080124.1; NM_001080125.1; NM_001228.4; NM_033355.3; NM_033356.3; NM_033358.3
• UniProt-Hinterlegungsnummer: Q14790
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CASP8(841)

Beschreibung

Allgemeine Beschreibung

Caspase-8 is a 55 kDa protein that binds to the death effector domain (DED) of FADD through an analogous DED domain present in the proform of caspase-8. Recruitment of caspase-8 to the Fas receptor results in oligomerization of the caspase-8 protein, which drives its auto-activation through self-cleavage. Active caspase-8 then proteolytically activates other downstream caspases including caspase-9, which lead to cell death.

Spezifität

Highly specific to caspase-8 and shows no cross-reaction with other caspase family members. This antibody recognizes the full length 55kDa caspase 8 on western blots.

Immunogen

Recombinant full-length human caspase-8 protein

Anwendung

Research Category
Apoptose & Krebs

Stoffwechsel

Research Sub Category
Kaspasen

Enzyme & Biochemie

Detect Caspase 8 using this Anti-Caspase 8 Antibody, clone 1-1-37 validated for use in WB.

Western blot: 1:100 - 1:1000

Optimal working dilutions must be determined by end user.

Verlinkung

Replaces: 04-573; 04-574

Physikalische Form

Format: Purified

Purified immunoglobulin by protein A. Liquid in PBS, pH 7.6, with 0.1% sodium azide.

Lagerung und Haltbarkeit

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable