554994

RHC-80267

Selective inhibitor of DAG lipase activity in canine platelets (IC₅₀ = 4 nM) and in a variety of mammalian cells.

• Synonym(e): RHC-80267, 1,6- bis(Cyclohexyloximinocarbonylamino)hexane
• Empirische Formel (Hill-System): C₂₀H₃₄N₄O₄
• CAS-Nummer: 83654-05-1
• Molekulargewicht: 394.51
• MDL-Nummer: MFCD00210844
• UNSPSC-Code: 51111800
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze
• Farbe: white to off-white
• Löslichkeit: DMSO: 25 mg/mL; ethanol: 25 mg/mL
• Versandbedingung: ambient
• Lagertemp.: 10-30°C
• InChI: 1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)
• InChIKey: RXSVYGIGWRDVQC-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Selective inhibitor of DAG lipase activity in canine platelets (IC₅₀ = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.

Biochem./physiol. Wirkung

Cell permeable: no

Primary Target
DAG lipase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 4 nM against DAG lipase activity in canine platelets

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Shinoda, J., et al. 1997. Arterioscler. Thromb. Vasc. Biol. 17, 295.
Shinoda, J., et al. 1997. Eur. J. Endocrinol. 136, 207.
Konrad, R.J., et al. 1994. Biochemistry 33, 13284.
Mason-Garcia, M., et al. 1992. Am. J. Physiol.262, C1197.
Balsinde, J., et al. 1991. J. Biol. Chem.266, 15638.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable