328500

ERO1 Inhibitor I, Erodoxin

The ERO1 Inhibitor I, Erodoxin controls the biological activity of ERO1.

• Synonym(e): ERO1 Inhibitor I, Erodoxin, 1-Bromo-5-methoxy-2,4-dinitrobenzene, Endoplasmic Reticulum Oxidase 1 Inhibitor
• Empirische Formel (Hill-System): C₇H₅BrN₂O₅
• CAS-Nummer: 181995-71-1
• Molekulargewicht: 277.03
• MDL-Nummer: MFCD00624873
• UNSPSC-Code: 12352200
• NACRES: NA.28

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥99% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: yellow
• Löslichkeit: DMSO: 100 mg/mL (Use only fresh DMSO)
• Versandbedingung: wet ice
• Lagertemp.: 2-8°C
• SMILES String: BrC(C=C(C([N+]([O-])=O)=C1)OC)=C1[N+]([O-])=O
• InChI: 1S/C7H5BrN2O5/c1-15-7-2-4(8)5(9(11)12)3-6(7)10(13)14/h2-3H,1H3
• InChIKey: SYWWRIKZBWQUGY-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable dinitrobromobenzene compound that acts as a selective inhibitor of yeast Endoplasmic Reticulum Oxidase 1 (ERO1), but has somewhat weaker activity against mouse ERO1α (IC₅₀ = 400 µM). Predicted to form thiol adducts and inhibits ERO1-dependent oxidation of thioredoxin-1 (Trx1) activity in vitro. Shown to cluster with genes involved in protein folding, glycosylation and cell wall biosynthesis, and delay carboxypeptidase Y (CPY) processing to the vacuolar form in wt-yeast cells.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 1 month at -20°C.

Sonstige Hinweise

Costanzo, M., et al. 2010. Science327, 425.
Blais, J.D., et al. 2010. J. Biol. Chem.285, 20993.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable