189404

Aurora Kinase Inhibitor II

The Aurora Kinase Inhibitor II, also referenced under CAS 331770-21-9, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(e): Aurora Kinase Inhibitor II, 4-(4ʹ-Benzamidoanilino)-6,7-dimethoxyquinazoline, Aurora Kinase Inhibitor II
• Empirische Formel (Hill-System): C₂₃H₂₀N₄O₃
• CAS-Nummer: 331770-21-9
• Molekulargewicht: 400.43
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥90% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: yellow
• Löslichkeit: DMSO: 5 mg/mL
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• InChI: 1S/C23H20N4O3/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)26-16-8-10-17(11-9-16)27-23(28)15-6-4-3-5-7-15/h3-14H,1-2H3,(H,27,28)(H,24,25,26)
• InChIKey: IMYVCWQAHSYYOO-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable anilinoquinazoline compound that acts as a potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC₅₀ = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.

A cell-permeable, potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC₅₀ = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
Aurora Kinase

Product competes with ATP.

Reversible: no

Target IC₅₀: 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Sonstige Hinweise

Heron, N.M., et al. 2006. Bioorg. Med. Chem. Lett.16, 1320.
Mortlock, A.A., et al. 2005. Curr. Top. Med. Chem.5, 807.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable